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Article History

Received: 19 August 2020

Accepted: 12 September 2020

First Online: 20 October 2020

Compliance with ethical guidelines

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: R. Mösges and S. Allekotte are employees of CRI—Clinical Research International Ltd. which served as the clinical research organisation for this study. E. Raskopf and C. Acikel were employees of CRI—Clinical Research International Ltd. at the time the study was conducted. R. Mösges reports personal fees from ALK, grants from ASIT biotech, personal fees from Allergopharma, personal fees from Allergy Therapeutics, grants and personal fees from Bencard Allergie GmbH, grants from Leti, grants, personal fees and non-financial support from Lofarma, non-financial support from Roxall, grants and personal fees from Stallergenes, grants from Optima, personal fees from Friulchem, personal fees from Hexal, personal fees from Servier, personal fees from Klosterfrau, non-financial support from Atmos, personal fees from Bayer, non-financial support from Bionorica, personal fees from FAES, personal fees from GSK, personal fees from MSD, personal fees from Johnson&Johnson, personal fees from Meda, personal fees and non-financial support from Novartis, non-financial support from Otonomy, personal fees from Stada, personal fees from UCB, non-financial support from Ferrero, grants from BitopAG, grants from Hulka, personal fees from Nuvo, grants from Ursapharm, outside the submitted work. S. Allekotte reports grants and personal fees from Lofarma, personal fees from Servier, personal fees from Hexal, personal fees from Friulchem, outside the submitted work. E. Raskopf reports personal fees from Bayer and personal fees from Gesellschaft für Phytotherapie outside the submitted work. P. Zieglmayer received lecture fees by Alk Abello, Allergopharma, Allergy Therapeutics, Novartis, Stallergenes, Thermo Fisher Scientific, and received scientific and educational grants by Allergopharma, Allergy Therapeutics, Biomay, Calistoga, GSK, HAL, MSD, Ono, Oxagen, RespiVert, Stallergenes and VentirX outside the submitted work. S. Weissenbaeck and M. Moser participated as investigators in this study. K. Birkholz, M. F. Kramer and S. Guethoff are employees of Bencard Allergie GmbH, Vienna, Austria and/or Munich, Germany, the sponsor of the study. C. Acikel declares that he has no competing interests.

: The study upon which this analysis was based was approved by the Medical Ethics Committee of Vienna, Austria (reference number EK16-192-1016). The study was registered at clinical trials.gov with number NCT03127436. Informed consent was obtained from all individual participants included in the study.