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Article History

Received: 18 February 2026

Accepted: 13 March 2026

First Online: 10 April 2026

Declarations

:

: Dara K. Shahrokh is an employee at JAMP Pharma. Ronald B. vender receives grants/research support, speakers bureau, honoraria from AbbVie, Alumis, Amgen, Arcutis, Bausch Health, Boehringer Ingelheim, Bristol Myers Squibb, Celltrion, Dermavant, Dermira, DICE, Eli Lilly, Galderma, Incyte, JAMP Pharma, Janssen, LEO, Meiji Seika Pharma, Nimbus Therapeutics, Novartis, Pfizer, Sanofi-Aventis, Sandoz, Sun Pharma, Takeda, UCB Pharma, Zai Lab Co. Ltd. Jaggi Rao receives grants/research support, speaker honoraria, and consulting fees from AbbVie, Actelion, Allergan, Amgen, Aspen, Bausch Health, Cipher, Clarion, Cutera, Cynosure, Eli Lilly, Galderma, Jan Marini, Janssen, L’Oreal, LEO Pharma, Lumenis, MD Medical, Medexus, Merz, Miravo, Novartis, Organon, Pfizer, Sandoz, Sanofi, Sciton, Seaford, Servier, Sun Pharma, Thermi, Vivier. Charles W. Lynde receives grants/research support, speaker honoraria, and consulting fees from AbbVie, Acelyrin, Akros, Altius, Amgen, Apogee, Aralez, Arcutis, Avillion, Bausch Health, Bayer, BioJAMP, Bioderma, Boehringer Ingelheim, Bristol Myers Squibb, Celgene, Celldex, Celltrion, CeraVe, Cipher, Concert, DICE, Dermavant, Dermira, Devonian, Eli Lilly, Evelo, Fresenius Kabi, GSK, Galderma, InCyte, Innovaderm, Intega Skin, Janssen, Kyowa Kirin, L’Oreal, LEO Pharma, La Roche Posay, MedX, Medexus, Merck, Moonlake, Naos, Nektar, Nimbus, Novartis, Organon, Oruka, P&G, PediaPharm, Pfizer, Regeneron, Roche, Sandoz, Sanofi, Sanofi Genzyme, Searchlight Pharma, Sentrex, Skinceuticals, Sun Pharma, Takeda, UCB, Volo Health, Vyne. Waqqas Afif is supported by the following companies: AbbVie, Amgen, Avir, BMS, Celltrion, Eli Lilly, Janssen, Innomar, Pfizer, Sandoz, Sanofi, Takeda. A. Hillary Steinhart is supported by the following companies: AbbVie, Amgen, Arena, BMS, Celltrion, Celgene, Ferring, Fresenius Kabi, Genentech, Gilead, JAMP Pharma, Janssen, Merck, Morphic Therapeutic, NKS Pharmacy, Pfizer, Pharmascience, Roche, Sanofi, Sandoz, Takeda. Neeraj Narula has received honoraria from Janssen, AbbVie, Takeda, Pfizer, Sandoz, Novartis, Iterative Health, Innomar Strategies, Fresenius Kabi, Amgen, Organon, Eli Lilly, and Ferring. Louis Bessette is supported by the following companies: Amgen, BMS, Janssen, UCB, AbbVie, Pfizer, Eli Lilly, Novartis, Sanofi, Teva, Fresenius Kabi, Sandoz, JAMP Pharma, Organon, a consultant for: Amgen, BMS, Janssen, UCB, AbbVie, Pfizer, Celgene, Eli Lilly, Novartis, Sanofi, Gilead, Teva, Fresenius Kabi, Sandoz, Organon, Sobi; and research: Amgen, BMS, Janssen, UCB, AbbVie, Pfizer, Celgene, Sanofi, Lilly, Novartis, Gilead, AstraZeneca, JAMP Pharma. Evelyn Sutton is on the steering committee of this study and is and ad board member for AbbVie and past president of CRA. Carter Thorne is supported by the following companies: AbbVie, Accord, Amgen, AstraZeneca, BI, Biogen, BMS, Celgene, CaRE-Biodam, Centocor, Genzyme, GSK, Hospira, JAMP, Janssen, Lilly, Medexus/Medac, Merck, Nordic, Novartis, Organon, Pfizer, Roche, Sandoz, Sanofi, Takeda, TcLand, and UCB.

: The study was conducted in accordance with the Declaration of Helsinki, the International Council for Harmonisation Good Clinical Practice guidelines, and the appropriate regulatory requirements in Canada. The protocol, its amendments, and informed consent documentation were reviewed and approved by the institutional review board(s) or independent ethics committee(s) at each study site. The study protocol (Protocol v2.0) was approved on March 3, 2023, by the independent Ethics Committee of Advarra (372 Hollandview Trail, Suite 300, Aurora, ON, L4G 0A5, Canada (Reference number Pro00069327)) and all study sites accepted the Advarra ethics committee approval. All patients provided written informed consent prior to entry to the study.