Funding for this research was provided by:
National Taiwan University (08SZA32502, 08SZA32501, 108TZA32, 108L104071)
Boehringer Ingelheim Taiwan (contract number 412850)
Article History
Accepted: 1 October 2020
First Online: 16 October 2020
Declarations
:
: The study was supported by the National Taiwan University (08SZA32502, 08SZA32501, 108TZA32, 108L104071) and Boehringer-Ingelheim Taiwan (contract number 412850) as an investigator initiated non-interventional study. The funding sources played no role in the execution, analysis, and interpretation of findings.
: K Arnold Chan was the principal investigator for several industry-sponsored studies during the design and execution of this study. Boehringer-Ingelheim is the manufacturer of pramipexole, the drug of interest in this study. The study team discussed with Boehringer-Ingelheim scientists the concept of the study before protocol development, but Boehringer-Ingelheim did not have input into the final study design, analysis, and interpretation of findings. Yu-Chun Hsieh and Shu-Feng Hsieh were research staff at the National Taiwan University Health Data Research Center and have no conflicts of interest to declare. Rou-Shayn Chen has served as a consultant and speaker for Boehringer-Ingelheim but has no conflicts of interest relevant to the content of this article and there are no other conflicts of interest to disclose.
: The study was approved by the Research Ethics Committee of National Taiwan University Hospital (approval document number 201901080 W). De-identified data were used and there was no contact with individual subjects.
: Requirement for individual consent was waived.
: Requirement for individual consent was waived.
: Per Taiwan government policy, source data and analytic data sets are kept at the Department of Statistics, Ministry of Health and Welfare and are not available for sharing with the research community.
: SAS codes for data development and analysis are available for review.
: The research concept was first proposed by Rou-Shayn Chen. K. Arnold Chan and Rou-Shayn Chen designed the study and prepared the protocol with assistance from Shu-Feng Hsieh. K. Arnold Chan and Rou-Shayn Chen applied for funding from sponsors, with K. Arnold Chan as the principal investigator. Yu-Chun Hsieh and Shu-Feng Hsieh supported project management, data development, analysis, and preparation of the report. K. Arnold Chan wrote the article.