Noda, Aoi http://orcid.org/0000-0002-7644-6848
Obara, Taku
Matsuzaki, Fumiko
Suzuki, Satoko
Arita, Ryutaro
Ohsawa, Minoru
Obara, Ryo
Morishita, Kei
Ueno, Fumihiko
Shinoda, Genki
Orui, Masatsugu
Murakami, Keiko
Ishikuro, Mami
Kikuchi, Akiko
Takayama, Shin
Ishii, Tadashi
Kawame, Hiroshi
Kure, Shigeo
Kuriyama, Shinichi
Funding for this research was provided by:
Japan Agency for Medical Research and Development (JP17km0105001, JP21tm0124005, JP21tm0424601)
Japan Society for the Promotion of Science (23K14378)
Article History
Accepted: 7 December 2023
First Online: 19 January 2024
Declarations
:
: The TMM BirThree Cohort Study protocol was reviewed and approved by the Ethics Committee of Tohoku University Tohoku Medical Megabank Organization (2013-1-103-1). Trained genome medical research coordinators were placed in each clinic, hospital, or community support centre to provide information on the TMM BirThree Cohort Study to potential participants and to receive signed informed consent forms from those who agreed to participate.
: Not applicable.
: The data obtained through the TMM BirThree Cohort Study are incorporated into the TMM biobank. All data analysed during the present study are available for research purposes with the approval by the Sample and Data Access Committee of the Biobank.
: R.A., M.O., A.K., S.T. and T.I. belong to the Department of Kampo and Integrative Medicine, Tohoku University School of Medicine. The department received a grant from Tsumura & Co, a Japanese manufacturer of Kampo medicine; however, the grant was used according to Tohoku University guidelines. Potential conflicts of interest were addressed by the Tohoku University Benefit Reciprocity Committee and were managed appropriately. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
: The TMM BirThree Cohort Study was supported by the Japan Agency for Medical Research and Development (AMED), Japan [grant number, JP17km0105001, JP21tm0124005, JP21tm0424601]. This work was supported by JSPS KAKENHI Grant Number 23K14378. Funding sources had no role in the study design, collection, analysis or interpretation of the data, writing of the manuscript, or decision to submit the paper for publication.
: AN was responsible for conducting the study, data analysis, interpretation of the results, and drafting of the manuscript. TO and SKuriyama supervised the study. TO, FM, FU, KM and MI contributed to the interpretation of results and provided critical feedback. TO, FM, SS, RA, MO, FU, KM, MI, AK, ST, TI, HK, SKure and SKuriyama provided advice on critically essential intellectual content and helped to draft the manuscript. All authors reviewed and approved the final manuscript.