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Article History

Accepted: 27 April 2025

First Online: 15 May 2025

Declarations

:

: This work was supported by Boehringer Ingelheim AB and Region Östergötland.

: M. Eklund declares no conflicts of interest. M. Husberg declares no conflicts of interest. T. Eriksson declares no conflicts of interest. M. Enoksson is currently employed at Boehringer Ingelheim AB. S. Gustavsson is currently employed at Boehringer Ingelheim AB. L-Å. Levin reports grants and personal fees from Bayer and Boehringer Ingelheim, and personal fees from Novartis, outside the submitted work. L. Bernfort declares no conflicts of interest.

: The research project of which this study is a part of has been approved by the Swedish Ethical Review Authority (Etikprövningsmyndigheten) Dnr. 2022-04543-01.

: Not applicable.

: Not applicable.

: The datasets generated and/or analyzed during the current study are not publicly available as the researchers do not have permission from the research ethics committee to share the data.

: Code is available at reasonable request to the corresponding author.

: M. Eklund, M. Husberg, L-Å. Levin, and L. Bernfort each contributed to the conceptualization and design of the study. M. Eklund drafted a significant portion of the manuscript. All authors contributed to analyzing the data and critically reviewing the manuscript. All authors read and approved of the final manuscript.