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Article History

Accepted: 5 March 2026

First Online: 17 April 2026

Declarations

:

: HCK, DTN, and RKR are employees of Viatris. All other authors declare no conflicts of interest associated with the publication of this study.

: Not applicable

: Not applicable

: Data and materials are not publicly available. However, they can be provided upon reasonable request to the corresponding author. Any further inquiries should be directed to the corresponding author.

: This is to declare that Pongsakorn, Julian, Yeh, Yeow, Chow, Kuhl and Nguyen and Rajesh contributed to constructing the concept and design of the study, all the authors contributed to data acquisition and interpretation, writing, editing and proofreading. All the authors have read and approved the final submitted manuscript and agreed to be accountable for the work.

: The study was reviewed and approved by the institutional review boards (IRBs) of the participating sites. The Ethics Committee of Jawatankuasa Etika Penyelidikan Manusia, Universiti Sains Malaysia (JEPeM-USM) (No. USM/JEPeM/21110747) approved this study in Malaysia. The Central Research Ethics Committee (CREC; no. COA-CREC017/2022) approved this study in Thailand. The research ethics committee of Hong Kong’s Doctor’s Union approved this study in Hong Kong. The Chang Gung Medical Foundation Institutional Review Board (IRB no.:202100254B0A3) approved the study in Taiwan.

: The patients provided written informed consent/pediatric assent. If the patient was minor, a parent or legal guardian must have provided written informed consent. The study followed all applicable laws and guidelines, the International Conference on Harmonization (ICH)/Good Clinical Practices (GCP), in accordance with the principles of the Declaration of Helsinki and the US Code of Federal Regulations (CFR).