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Article History

Received: 25 February 2024

Accepted: 29 July 2024

First Online: 12 September 2024

Declarations

:

: All authors have approved the manuscript and agree with its submission to Sleep and Biological Rhythms. All authors certify that they have no affiliations with or involvement in any organization or entity with any financial interest or non-financial interest in the subject matter or materials discussed in this manuscript.

: This clinical trial falls under off-label use of the drug, and is registered with the Japan Registry of Clinical Trials and has received approval. The registration number is jRCTs041180086. UMIN Clinical Trials Registry: UMIN000027645 Clinical study about the safety of Orexin receptor antagonist Suvorexant for severe sleep apnea syndrome URL:

: Informed consent was obtained from all individual participants included in the study.

: All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards. This article does not contain any studies with animals performed by any of the authors.