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Article History

Accepted: 27 March 2022

First Online: 5 May 2022

Declarations

:

: Cancer Australia, Priority-driven Collaborative Cancer Research Scheme project #1046923. Rachael L. Morton is supported by a NHMRC investigator fellowship (#1194703) and a University of Sydney Robinson Fellowship.

: Angela M Hong has received consultancy fees and honorarium from Amgen and Bayer. Anh D Tran, Mai TH Nguyen, Gerald Fogarty, Victoria Steel, Elizabeth Paton, and Rachael L Morton have no conflicts of interest that are directly relevant to the content of this article.

: The datasets generated during and/or analysed during the current study are not publicly available because individual trial participants have not provided consent for the sharing of this information. A de-identified dataset may be made available from the corresponding author on reasonable request with a research proposal.

: Not applicable.

: ADT designed the analysis, conducted data analysis, and wrote the manuscript. MTHN wrote part of the manuscript and presented the tables. VS and EP undertook Medicare coding, cleaned the data, and commented on the manuscript. AH, GF, and RLM designed the study, interpreted findings, wrote and critically reviewed the manuscript, and supervised the research team.

: The study protocol was approved by the Cancer Institute New South Wales Ethics Committee (reference 2007C/11/032) and the Sydney Local Health District Ethics Committee (reference X13-0329 and HREC/13/RPAH/465) as well as by institutional review boards at each site. The trial was registered with the Australian Clinical Trials Registry (ACTRN12607000512426) and ClinicalTrials.gov.

: Patients provided their consent to participate prior to participation via ethically approved specific consent forms.

: The consent form also specified that the anonymized results of the study (primary, secondary and tertiary endpoints) would be published, and all patients who consented using the form also agreed in principle to the publication arrangement.