Afentou, Nafsika
Frew, Emma http://orcid.org/0000-0002-5462-1158
Mehta, Samir
Ives, Natalie J.
Woolley, Rebecca L.
Brettell, Elizabeth A.
Khan, Adam R.
Milford, David V.
Bockenhauer, Detlef
Saleem, Moin A.
Hall, Angela S.
Koziell, Ania
Maxwell, Heather
Hegde, Shivaram
Finlay, Eric
Gilbert, Rodney D.
Jones, Caroline
McKeever, Karl
Cook, Wendy
Webb, Nicholas J. A.
Christian, Martin T.
Webb, Nicholas
Christian, Martin
Ives, Natalie
Frew, Emma
Brettell, Elizabeth
Barsoum, Emma
Bodenham-Chilton, Helen
Khan, Adam
Akhtar, Noreen
Hunt, Charmaine
Galinha, Carla
Smith, Dominique
Winkles, Neil
Ives, Natalie
Woolley, Rebecca
Mehta, Samir
Moakes, Catherine
Frew, Emma
Afentou, Nafsika
Cook, Wendy
Cope, Sandra
Thomas, Megan
Coad, Nigel
Cope, Sandra
Green, Darren
Hillman, Kate
Ibrahim, Zala
Yu, Ly-Mee
Watson, Alison
Bibi Team, Fatima
Moya, Eduardo
Saleem, Moin
Kelly, Alison
Crosbie, Eilean
Swingler, Rachel
Kilroy & Team, Susan
Ayonrinde, Oyekunle
Smith, Amanda
Turner, Andrea
Campbell, Jonathan
Turner, Aine
Brearey, Stephen
Burchett, Caroline
De-Beger, Sarah
Fenton, Theo
Jones, Glyn
Kelsall, Nicci
D’Costa, Selwyn
Jayachandran, Dinakaran
Nair Catherine Tarn Nozedar, Asha
Egginton, Dawn
Cuthell, Oliver
Derry, Catherine
Natesan, Kathiresan
Sharman, Sarah-Jane
Singh, Rajeeva
Deakin, Kathryn
Castle Team, Gail
Wobi, Bukar
Etuwewe, Bemigho
Burnett & Team, Caroline
Khoobarry, Kamal
Whincup, Graham
Cowley, Anne
Koziell, Ania
Sinha, Manish
Reid, Christopher
Ahmad & Team, Mohammad
Padmakumar, Beena
Magadevan, Talaivirichan
O’Connor, Grainne
Woodhead, Louise
Formosa, Mireille
Nardeosingh, Nayan Peepah
Allison, Kathryn
Hesseling, Markus
Bolger, Annette
Hobson & Team, Lucie
Sambo, Adamu
Jadresic, Lyda
Beames, Susan
Bockenhauer, Detlef
Hothi, Daljit
Vella, Elizabeth
Linton, Corinne
Yussuf, Shaima
Bazaya, Tendai
Abou-Rayyah & Team, Mahmoud
West, Nick
Sood, Rajiv
De Jesus & Team, Hilarious
Gupta, Vikas
Mathew, Verghese
Bentsi-Enchill, Esi
Davison, Allyson
Craze, Janet
Rfidah, Elhussein
Musselwhite, Janine
Moon & Team, Angela
Bilolikar, Harsha
White & Team, Sonia
Rhodes, Simon
Moulds, Caroline
Prajapati, Hitesh
Finlay, Eric
Yadav, Pallavi
Newnham, Amanda
Tyerman, Kay
Allen, Majorie
Wellings & Team, Lucy
Hall, Angela
Philps & Team, Jackie
Kaviethasan, Subajini
Smith & Team, Sally
Broodbank, David
Mukhopadhyay, Sourabh
Gupta, Ruchika
Roper, Amanda
Butler & Team, Susie
Rajkowski, Tomasz
Eisenhut, Michael
Duncan, Karen
Samm, Karen
Clough & Team, Samantha
Wright, David
Thattakkat, Krishnakumar
Losa, Ignatius
Keenan & Team, Natalie
Balasubramanian, Krishnan
Javed, Muhammad
Kempson, Sharon
Phipps & Team, Marie
Cansick, Janette
Msiska, Maines
Anguvaa, Lazarus
Aye, Mya
Conway, Sally
Beer, Natalie
Wright & Team, Francesca
Langlands, Jennifer
O’Brien, Kirsty
Thorne & Team, Nicola
Davies, Karen
Kempson, Sharon
Phipps & Team, Marie
Parikh, Ami
Gadong, Nimze
Anjum, Bahadur
Plaatjies, Nicolene
Lancoma-Malcolm, Ivone
De Jesus & Team, Hilarious
Datta, Vipan
Upton, Chris
Fear, Louisa
Coke & Team, Louise
Dalton, Dermot
Holbrook & Team, Becky
Norton, Imogen
Christian, Martin
Lunn, Andrew
Vincent, Olivia
Navarra, Helen
Khan & Team, Neelam
Aslam, Mona
Goodyear, Paula
Wadams, Steve
Power, Susan
Roff & Team, Amy
Gupta, Manish
Ayub, Naeem
Owen & Team, Charlotte
Scanlan, Judith
McCready, Sharon
Gribbin, Andrew
Ahmed, Mansoor
Muogbo, Dominic
Carswell, Heather
Boswell, Stephanie
Backhouse & Team, Claire
Solebo, Junaid
Smith, Helen
Webb, Alan
Logie, Ing-Marie
Dekker, Sandra
Suri, Sanjay
Shackleton & Team, Janet
Oxley, Craig
Connon & Team, Margaret
Joshi, Vineeta
Pemberton & Team, Nicola
Maxwell, Heather
Sharma, Amita
Waxman & Team, Elizabeth
McKeever, Karl
Millar & Team, Muriel
Gordon, Ann
Edees, Susan
Hallett & Team, Susan
Iqbal, Javed
von Bremen, Beate
Collier, Heather
Lancaster & Team, Andrew
Watson, Fiona
Henry & Team, Joanne
Bowker, Richard
Smith, Coral
Cottis, Hannah
Samuel, Rebecca
Harrill, Caroline
Wilkins & Team, Suzanne
Maxwell, Heather
Reynolds, Ben
Hughes, David
Elizabeth,
Team, Waxman
Reynolds, Ben
Hughes, David
McGregor, Tracey
Ramsay, Maxine
Baggott, Julie
Matos & Team, Naomi
Jones, Caroline
Morgan, Henry
Holt, Richard
Theresa Moorcroft, Louise Oni
Shakeshaft & Team, Joanne
Shenoy, Mohan
Webb, Nicholas
Kaur, Amrit
Wallace, Dean
Plant, Nicholas
Sukthankar, Shaila
Branson, Angela
Blackburn, Helen
Howell, Jane
Nichols & Team, Jess
Basharat, Furqan
Raja, Saeeda
Phipps, Marie
Parker, Helen
Tomlinson, Joanne
Roe & Team, Eric
Diskin, Lynn
Barratt, Alison
Mahadevan-Bava, Subramanian
Weston, Abigail
Kaur, Daljit
Venkatesh, Udupa
Temlett, Emma
Dyer, Simon
Elliott, Kerry
Furness & Team, Rosie
Lunn, Andrew
Shackleton, Janet
Shortland, Sarah
Murray & Team, Miranda
Gilbert, Rodney
Harmer, Matthew
Haq, Shuman
Fairhead, Lisa
Haskell, Louise
Bingham & Team, Victoria
Shrivastava, Anupam
Hove, Onie
Hadebe, Bernard
Magier, Christopher
Harms, Bettina
Butterworth, Sian
Bhatti, Tariq
Parker, Aisling
Walding & Team, Lorna
Brennan, Nicholas
Brennan, Nicholas
Cooper, Chris
Bennett & Team, Sara
Date, Anjali
Petkar, Anjali
Hulse & Team, Wendy
Ahmed, Munir
Dawson, Tom
Rowlands Stephanie Chamberlain, Connie
Meyrick, Simon
Darwood, Iain
Collins, Emma
Lall, Rajesh
Onifade, Elizabeth
Green Team, Joanna
Johnson, Sally
Lambert, Heather
Tse, Yincent
Malina, Michal
Sathyanarayan, Vijaya
Booth, Jenny
Bell, Kathryn
Crulley & Team, Stephen
Buck, Jackie
Beeby, Deborah
Hunt & Team, Louise
Sandhu, Sundeep
Millman, Gur
Wheeler, Murray
Clayton, Anna
Thompson & Team, David
Oates, Bridget
Bell, Claire
Wardrop & Team, Joanna
Tandle, Vijay
Campbell, Carolyn
Egginton & Team, Dawn
Hegde, Shivaram
Krishnan, Rajesh
Morrison, Zoe
Muller, Jennifer
Yendle & Team, Louise
Webb, Delyth
Rogers, Natalie
Elhadi, Nour
Shah, Dipali
Sayan & Team, Amrinder
Cesar, Karine
Lakshman, Raman
Cockerill, Helen
Huma, Zilla
Thin Saing, Thin
Brown, Angela
Leitch & Team, Karen
Vemuri, Gopi
Holliday, Claire
Carey, Jessica
Woodhead & TeamMadalitso Kubwalo, Louise
Bolger & Team, Annette
,
Funding for this research was provided by:
Health Technology Assessment Programme
Article History
Accepted: 28 March 2022
First Online: 22 June 2022
Declarations
:
: Martin T. Christian reported serving as a member of the Clinical Practice Guideline Group for Steroid Sensitive Nephrotic Syndrome of the International Pediatric Nephrology Association during the conduct of this study. Nicholas J.A. Webb reported being an employee of Novartis since August 2018 outside the submitted work. Nafsika Afentou reported receiving grants from the National Institute for Health Research (NIHR) outside the submitted work. Emma Frew reported receiving grants from the NIHR and Zhejiang Yongning Pharmaceutical Co. Ltd outside the submitted work. Elizabeth A. Brettell reported receiving grants from the NIHR during the conduct of this study. David V. Milford reported receiving grants from the NIHR during the conduct of this study. Natalie J. Ives reported receiving grants from the NIHR during the conduct of this study. Samir Mehta, Rebecca L. Woolley, Adam R. Khan, Detlef Bockenhauer, Moin A. Saleem, Angela S. Hall, Ania Koziell, Heather Maxwell, Shivaram Hegde, Hitesh Prajapati, Rodney D. Gilbert, Caroline Jones, Karl McKeever, and Wendy Cook have no conflicts of interest to declare.
: This project was funded by the NIHR Health Technology Assessment programme.
: Nafsika Afentou undertook the health economic evaluation supervised by Emma Frew. Samir Mehta and Rebecca Woolley undertook statistical analyses, supervised by Natalie Ives, and provided statistical input into the economic evaluation and the trial design. Elizabeth Brettell and Adam Khan supervised the central team at Birmingham Clinical Trials Unit and co-ordinated governance of the trial. David Milford, Detlef Bockenhauer, Moin Saleem, Angela Hall, Ania Koziell, Heather Maxwell, Shivaram Hegde, Eric Finlay, Rodney Gilbert, Caroline Jones and Karl McKeever were co-applicants to the NIHR HTA grant and were principal investigators to the trial in their own institutions. Wendy Cook, the director of the Nephrotic Syndrome Trust (NeST), contributed to the trial design and provided input into parent/children-facing documents. Nicholas Webb conceived the idea for the trial, led the design of the protocol, was principal applicant for the NIHR HTA grant and was chief investigator until 2018. Martin Christian was a co-investigator within the grant application and chief investigator to the trial from 2018. Nafsika Afentou and Emma Frew led on writing the manuscript and all authors edited the manuscript.
: Ethics approval for the PREDNOS2 trial was granted by the National Research Ethics Service Committee North West—Greater Manchester Central (reference 12/NW/0766) on 4 December 2012.
: Not applicable.
: Not applicable.
: Not applicable.
: Not applicable.