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Article History

Accepted: 22 August 2024

First Online: 8 October 2024

Declarations

:

: Funding for this study was provided by Takeda Pharmaceuticals International AG.

: Aren Fischer is a former employee of Takeda Canada Inc. and is now an employee of Alexion Pharmaceuticals. Stephen Mac and Erica Stivelman Freiman are employees of Takeda Canada Inc. John K. Marshall has received honoraria for speaking and/or consulting from AbbVie, Allergan, Amgen, Bristol Myers Squibb, Ferring, Fresenius Kabi, Janssen, Lilly, Lupin, Merck, Novartis, Paladin, Pfizer, Pharmascience, Procter & Gamble, Roche, Shire, Takeda, and Teva. Juan M. Ramos-Goni and Kim Rand are employees of Maths in Health, which received funding from Takeda.

: Not applicable.

: Not applicable.

: Not applicable.

: The datasets, including the redacted study protocol, redacted statistical analysis plan, and individual participant data supporting the results reported in this article will be made available within 3 months from initial request, to researchers who provide a methodologically sound proposal. The data will be provided after its de-identification, in compliance with applicable privacy laws, data protection, and requirements for consent and anonymization.

: The model is proprietary and cannot be shared or published. If additional sensitivity analyses or scenarios are desired, please contact the corresponding author.

: All authors contributed to the study conception and design. Material preparation and data collection and analysis were performed by Aren Fischer, Stephen Mac, Erica Stivelman Freiman, Kim Rand and Juan M. Ramos-Goñi. The first draft of the manuscript was written by Pedro Serrano and Anabel Estevez-Carillo as per content input from authors, and all authors commented on further versions of the manuscript. All authors read and approved the final manuscript.

: Medical writing support was provided by Pedro Serrano and Anabel Estevez-Carillo of Maths in Health and was funded by Takeda.