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Article History

Accepted: 24 March 2025

First Online: 15 April 2025

Declarations

:

: E.L., T.P., A.L., C.D., and E.G. conceived the study and methodology. A.L., E.L., and T.P. validated the data, conducted project administration, and supervised the study. C.D. and E.G. performed the analysis and investigation and visualized the data. All authors wrote the first draft and reviewed and edited previous versions of the manuscript. All authors read and approved the final manuscript.

: This study was supported by Pfizer Inc, New York, USA, and the publication fees were covered by Pfizer Inc.

: C.D., E.G., and A.L. are employees of Acaster Lloyd Consulting Ltd, which was paid a fixed fee for working on this research project. A.L. is a stockholder in Acaster Lloyd Consulting Ltd. T.P. and E.H.L. are employees of and hold stock or stock options in Pfizer.

: The final protocol, any amendments, and informed consent documentation were reviewed and approved by an institutional review board and/or independent ethics committee for each site participating in the study.

: The data that support the findings of this study are available from the corresponding author upon reasonable request.

: Not applicable.

: Signed informed consent was obtained prior to participants entering the study.

: The data were anonymized, and the submission does not include personal details or images that may lead to the identification of participants, and, therefore, consent to publish was not required.