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Article History

Accepted: 15 June 2025

First Online: 5 August 2025

Declarations

:

: All authors state that they have no relevant conflict of interests which could have an impact on study design, analysis or the presentation of findings.

: The present research work was conducted without funding.

: All authors made a meaningful contribution to the conception, design, analysis and interpretation of data, elaboration and critical review of the manuscript, approved the final manuscript and agreed to assume responsibility for all aspects of the work.

: The corresponding author, on behalf of all other co-signatories, guarantees the accuracy, transparency and veracity of the data and information contained in the present manuscript. They also guarantee that no relevant information has been omitted and that all disagreements between authors have been appropriately resolved and discussed.

: Not applicable.

: Not applicable as no human participants were involved in this study.

: Not applicable, as no patient data or individual participant information is included in this study.

: The data inputs used in the analyses—including clinical efficacy, utility values, and cost parameters—are described in detail in the manuscript and supplementary materials and were obtained from published literature and official Spanish healthcare databases. Any additional datasets generated during the current study are available from the corresponding author upon reasonable request.

: The economic evaluation and budget impact analysis were conducted using Microsoft Excel 2016, employing a partitioned survival model to estimate costs and health outcomes. The Excel model(s) used for these analyses are available from the corresponding author upon reasonable request.