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Article History

Received: 2 June 2025

Accepted: 29 October 2025

First Online: 23 January 2026

Declarations

:

: LM and TH are employed by Thermo Fisher Scientific, a company that received funding from Johnson & Johnson Innovative Medicine for time spent conducting this research. QZ and TD are employed by Johnson & Johnson Innovative Medicine and hold company stocks.

: Aggregated data can be shared upon reasonable request.

: The study protocol was approved by an institutional review board (Salus IRB; Study 23234-01), and the study was conducted per the ethical standards as defined in the 1964 Declaration of Helsinki and its later amendments.

: All authors contributed to the study conception and design. Material preparation, data collection, and analysis were directed by Timothy Howell and Louis Matza. The first draft of the manuscript was written by Timothy Howell and Louis Matza. The other authors provided edits and comments on the manuscript drafts. All authors read and approved the final manuscript.

: All participants signed a form indicating informed consent to participate.

: The consent form signed by participants included consent for the results of the study to be published.

: Not applicable.