Burgess, Colleen https://orcid.org/0000-0003-0393-0767
Kujawski, Stephanie A. https://orcid.org/0000-0001-7915-8553
Amorim, Miguel https://orcid.org/0009-0008-0400-8305
Lang, John C. https://orcid.org/0000-0002-1770-2995
Funding for this research was provided by:
Merck
Article History
Received: 2 September 2025
Accepted: 1 June 2026
First Online: 29 June 2026
Declarations
:
: This work was supported by Merck Sharp & Dohme LLC, a subsidiary of Merck & Co., Inc., Rahway, NJ, USA.
: JCL is an employee of Merck Canada Inc., a subsidiary of Merck & Co., Inc., Rahway, NJ, USA. CB is a contractor with Merck Sharp & Dohme LLC, a subsidiary of Merck & Co., Inc., Rahway, NJ, USA, and was compensated for her work. MA is an employee of MSD (Portugal) Lda., a subsidiary of Merck & Co., Inc., Rahway, NJ, USA. SAK is an employee of Merck Sharp & Dohme LLC, a subsidiary of Merck & Co., Inc., Rahway, NJ, USA. JCL, MA, and SAK may hold stock and/or stock options in Merck & Co., Inc., Rahway, NJ, USA.
: The data underlying this article are available in the article and in its online resources.
: Not applicable.
: Not applicable.
: Not applicable.
: Conceptualization: SAK, MA, and JCL. Methodology: CB, SAK, and JCL. Data curation/software/formal analysis/visualization: CB and JCL. Validation: CB, SAK, MA, and JCL. Investigation: CB, SAK, and JCL. Writing – original draft: CB and SAK. Writing – review and editing: CB, SAK, MA, and JCL.
: The Mathematica model is not publicly shared. Additional details necessary to reproduce the analyses are available from the corresponding author upon reasonable request.