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Article History

Received: 11 December 2024

Accepted: 5 May 2025

First Online: 21 May 2025

Declarations

:

: The need for ethical approval was waived off by the ethical committee of Bloomage Biotechnology Co., Ltd in accordance with the Cosmetic Safety Technical Specifications 2015 issued by the State Food and Drug Administration of China. The human patch test is a kind of safety test that is non-invasive. The written informed consent was obtained from all individual participants included in the patch test.

: The need for ethical approval was waived off by the ethical committee of Bloomage Biotechnology Co., Ltd based on SN/T 2329–2009 Cosmetics Ocular Irritant and Corrosive HET-CAM Test. The chick chorioallantoic membrane (CAM) assay is a kind of safety test. It used immature living organism while adhering to the “Three R strategy” established by Russell and Burch.

: Not applicable.

: The authors declare that they are the owners of the patents (patent name: RECOMBINANT TYPE-III COLLAGEN AND METHOD FOR PREPARING SAME, patent number: CN 114805551 B and WO 2024/002149 A1) relevant to the work. The patent has been completed and published. In the interest of fairness, openness and transparency, we are willing to disclose this information. However, we warrant that this patent has not affected the design, implementation, interpretation and writing of the results of this paper.