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Authors
Tabb, David L.
Kaniyar, Mohammed Hanzala
Bringas, Omar G. Rosas
Shin, Heaji
Di Stefano, Luciano
Taylor, Martin S.
Xie, Shaoshuai
Yilmaz, Omer H.
LaCava, John
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Funding
Funding for this research was provided by:
National Institute on Aging (R01AG078925, R01AG078925, R01AG078925, R01AG078925, R01AG078925, R01AG078925)
Kenneth Rainin Foundation (Innovator Award #20230023, Innovator Award #20230023, Innovator Award #20230023)
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Article History
Received: 2 August 2024
Revised: 2 August 2024
Accepted: 3 September 2024
First Online: 17 September 2024
Declarations
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: The authors declare no competing interests.
: All animal experiments were performed in the laboratory of Dr. O, Yilmaz, at the Koch Institute at the Massachusetts Institute of Technology in accordance with the Institutional Animal Care and Use Committees (IACUC) and relevant guidelines at MIT, with protocols 1219–076-22 and 2210000430. All animals were C57BL/6 J genetic background. Strains include Rosa26 (lsl-tmem192-3xHA, Jackson laboratory stock # 0354010), Villin-CreERT2 (Jackson laboratory stock # 035595), and Lgr5-CreERT2 (). Both male and female age-matched mice from 8 to 12 weeks of age were used for all experiments in this study. Littermates of the same genotype, sex, and age were randomly assigned to experimental groups. All mice were housed under specific-pathogen-free (SPF) conditions at the Koch Institute at MIT animal facilities, except the germ-free animals housed separately under the supervision of Dr. James Fox (MIT Comparative Medicine).
