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Polyherbal Therapeutics Mitigate CCl4-Induced Testicular Toxicity through Modulation of SHBG, AKT1, and AR Pathways: An Integrated In Vitro, In Vivo, and In Silico Approach

Crossref DOI link: https://doi.org/10.1007/s43032-025-01998-1

Published Online: 2025-11-13

Published Print: 2025-12

Update policy: https://doi.org/10.1007/springer_crossmark_policy

Authors

Hussain, Shoukat

Javed, Alia

Razia, Dur EMaknoon

Ashiq, Naosheen

Iqbal, Muhammad Javid

Jahangeer, Muhammad

Shaheen, Uzma

Yameen, Muhammad

Shahzad, Asif https://orcid.org/0009-0004-5132-6155
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Text and Data Mining valid from 2025-11-13

Version of Record valid from 2025-11-13
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Article History

Received: 15 May 2025

Accepted: 7 October 2025

First Online: 13 November 2025

Declarations

:

: This animal study was reviewed by the Government College University Faisalabad (GCUF) Ethics Committee. The protocol was evaluated against the institutional ethical guidelines and the national standards for the care and use of laboratory animals. The committee approved the protocol under the reference number: GCUF/ERC/334. All the procedures involving animals were conducted according to the principles stated in the Guide for the Care and Use of Laboratory Animals (National Research Council) and in accordance with the ethical considerations of animal welfare and humane treatment.

: The authors declare no competing interests.

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