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Authors
Kazerani, Mahsa
Cagiral, Umut
Tabatabaei, Seyedeh Zoha
Akalper, Remziye Nur
Bora, Ugur
Babashah, Sadegh
Ozhan, Gunes
Totonchi, Mehdi https://orcid.org/0000-0002-7285-3155
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Funding
Funding for this research was provided by:
Izmir Institute of Technology
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Article History
Received: 14 July 2025
Accepted: 19 March 2026
First Online: 4 May 2026
Declarations
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: The study protocol received ethical approval from the Institutional Review Board of the Ethics Committee of Tarbiat Modares University (Approval No. IR.MODARES.REC.1403.061) and the Royan Institute Ethics Committee (IR.ACECR.ROYAN.REC.1397.01). All animal procedures complied with the European Union Directive 2010/63/EU on the protection of animals used for scientific purposes and were approved by the Animal Experiments Local Ethics Committee of the Institute of Biomedical Genetics (IBG-AELEC) and adhered to ARRIVE guidelines for animal research.
: All participants, including proband and other family members, voluntarily provided written informed consent after receiving detailed explanations of the study’s objectives, methodologies, and potential implications. Procedures adhered to the ethical principles outlined in the Declaration of Helsinki (1975) and complied with local regulations governing human biomedical research. Confidentiality of participant data was rigorously maintained, with anonymized identifiers used throughout the investigation.
: Not applicable.
: The authors declare no competing interests.
