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Synthesis and evaluation of KR-12, an LL-37 fragment, and its short-chain fatty acid derivatives: selective cytotoxicity in colorectal cancer cells and anti-tumor efficacy in an azoxymethane/DSS-induced colitis-associated cancer mouse model

Crossref DOI link: https://doi.org/10.1007/s43440-025-00790-x

Published Online: 2025-10-15

Update policy: https://doi.org/10.1007/springer_crossmark_policy

Authors

Włodarczyk, Jakub

Kamysz, Elżbieta

Fichna, Jakub
Funding

Funding for this research was provided by:

Ministerstwo Edukacji i Nauki (#0018/DIA/2019/48)

Uniwersytet Gdański (#531-T040-D838-25)

Uniwersytet Medyczny w Lodzi (503/1-156-04/503-11-001)
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Text and Data Mining valid from 2025-10-15

Version of Record valid from 2025-10-15
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Article History

Received: 5 July 2025

Revised: 30 September 2025

Accepted: 6 October 2025

First Online: 15 October 2025

Declarations

:

: Not applicable.

: All procedures involving animals were in compliance with the European Community Council Directive of 24 November 1986, and ethical approval was granted by the Local Ethical Committee for Animal Research at the Medical University of Lodz with the following number: 33/ŁB145/2019.

: The authors declare no competing interests.

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