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Authors
Jones, Sal https://orcid.org/0000-0003-2351-8622
Ashworth, Jennifer C. https://orcid.org/0000-0003-4189-8876
Meakin, Marian
Collier, Pamela
Probert, Catherine
Ritchie, Alison A. https://orcid.org/0000-0002-5092-4979
Merry, Catherine L. R. https://orcid.org/0000-0002-3490-2809
Grabowska, Anna M. https://orcid.org/0000-0003-1507-921X
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Funding
Funding for this research was provided by:
National Centre for the Replacement, Refinement and Reduction of Animals in Research (NC/P002285/1, NC/N0015831/1, NC/T001267/1, NC/T001259/1)
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Article History
Received: 8 November 2022
Revised: 14 March 2023
Accepted: 15 March 2023
First Online: 9 May 2023
Declarations
: All in vivo work was carried out under project licence PPL 3003444 and with the approval of the University of Nottingham AWERB (Animal Welfare and Ethical Review Body).
: NCRI guidelines for the welfare and use of animals in cancer research, LASA good practice guidelines and FELASA working group on pain and distress guidelines were also followed, as were the ARRIVE guidelines on the reporting of in vivo experiments.
: PDXs were originally established from patient samples are collected as fresh surgical material from tumour resections at UN Hospitals NHS Trust, collected with informed patient consent and National Research Ethics Service (NRES) approval (NRES REC 10/H0405/6) and used in accordance with NRES approval (NRES REC 08/H0403/37).
: The authors declare no competing interests.
