Document is current

Article History

Received: 26 April 2023

Accepted: 1 August 2023

First Online: 29 August 2023

Declarations

:

: The legal guardians of all patients enrolled in the parent <i>RESTORE</i> and <i>BALI</i> studies provided informed consent for the enrollment of their child in these studies. Child assent was waived by the Internal Review Boards because eligible subjects were typically sedated during their treatment and study course, rendering them unable to provide assent.

: The authors declare the following financial interests/personal relationships which may be considered as potential competing interests:Drs. Matthay, Flori, Sapru, Curley, Quasney, Dahmer, and Flori reports financial support was provided by the National Heart Lung and Blood Institute. Dr. Ward reports financial support was provided by the National Institute of Child Health and Human Development. Dr. Flori reports a non-financial advisory relationship with Aerogen Pharma and Lucira Health, Inc. Dr. Liu serves as a consultant for Biomerieux, BOA Medical, and Seastar Medical. Dr. Liu reports a relationship with Amgen Inc that includes equity or stocks. Dr. Liu serves on the Editorial Boards of the American Journal of Kidney Diseases, American Journal of Respiratory and Critical Care Medicine, and CJASN, and as a scientific advisor of the NKF Scientific Advisory Board and American Thoracic Society. Dr. Matthay has received grant funding from Roche-Genetech, not associated with the work of this manuscript. Dr. Matthay serves as a consultant for Citrus Pharmaceuticals Johnson & Johnson, Gilead Pharmaceuticals, Plant Therapeutics, Novartis Pharmaceuticals, and AM Pharma.