Li, Nan
Zhang, Ruiqin
Deng, Xue
Gu, Xiaofan
Wang, Jingxia
Xu, Qiulin
Zhang, Xiongwen
Guo, Xiaodong
Liu, Xuan
Funding for this research was provided by:
The Key Fields Excellent Ph.D Student Education Program of Shanghai University of TCM (GJ2023031)
National Nature Science Foundation of China (82373317, 82374085)
Natural Science Foundation of Shanghai (21ZR1464400, 23ZR1460500)
Article History
Received: 10 April 2024
Accepted: 1 July 2024
First Online: 17 September 2024
Declarations
:
: The present study has been approved by the Institutional Animal Care and Use Committee of the Shanghai University of Traditional Chinese Medicine (NO. PZSHUTCM2304070004).
: The tumor size/burden in the present study was not exceeded the maximal tumor size/burden permitted by the ethics committee, the Institutional Animal Care and Use Committee of the Shanghai University of Traditional Chinese Medicine. Generally, the maximal tumor size/burden permitted by the Institutional Animal Care and Use Committee of the Shanghai University of Traditional Chinese Medicine is that, the tumor volume in mice should not exceed 2000 mm<sup>3</sup> or the weight of the tumor should not be more than 10% of the body weight of the mice. While, since cancer cachexia is a syndrome observed in cancer patients in the late stages of the disease, larger tumor size/burden was necessary for studies establishing animal models of cancer cachexia. For example, more than 8000 mm<sup>3</sup> tumor volume was observed in previous studies []. Therefore, no specific limitation of tumor size/burden is required for cancer cachexia-related studies.
: The authors declare that they have no competing interests.