Iff, Joel https://orcid.org/0000-0002-1102-0651
Shah, Ankit
Lin, Wei
Fillbrunn, Mirko
Maski, Manish
Gomes, Dumingu Aparna
Huang, Rui
Tuttle, Edward
Barber, Beth
Article History
Received: 8 May 2026
Accepted: 7 July 2026
First Online: 29 July 2026
Change Date: 19 August 2026
Change Type: Update
Change Details: This article was updated to correct Fig. 2c. During production a white space was introduced into the image blocking some of the data. The error was not fault of the authors.
Change Date: 11 September 2026
Change Type: Update
Change Details: This article was updated to add the visual abstract.
Change Date: 28 August 2026
Change Type: Correction
Change Details: A Correction to this paper has been published:
Change Details: https://doi.org/10.1007/s44531-026-00009-z
Declarations
Conflicts of interest: JI, AS, WL, MM, and BB are employees of Vertex Pharmaceuticals Incorporated and may own stock or stock options in the company. MF, DAG, RH, and ET are employees of Analysis Group Incorporated, a consulting firm retained by Vertex Pharmaceuticals Incorporated to conduct research pertaining to this work.