Shao, Junwei
Ge, Tiantian
Tang, Cuilan
Wang, Gang
Pang, Lantian
Chen, Zhi
Funding for this research was provided by:
National Science and Technology Major Project of China (2017ZX10202203)
Article History
Received: 7 August 2022
Revised: 17 August 2022
Accepted: 22 August 2022
First Online: 17 September 2022
Declarations
:
: The authors declare no competing interests.
: The authors declare that there is no conflict of interest regarding the publication of this paper.
: Lithocholic acid (LCA) achieves anti-inflammatory and anti-fibrotic effects in the liver by regulating the differentiation of macrophages and inhibiting the activation of hepatic stellate cells (HSCs). The impacts of LCA on liver fibrosis need the synergistic effects of the gut microbiota.
: The First Affiliated Hospital of Zhejiang University School of Medicine ethics committee approved these animal experiments in accordance with Helsinki ethics committee guidelines. Informed consent was obtained from all participants. The Ethics Committee approved the experimental protocol of the same hospital (V2.0/20190503).
: All authors agree to publish.