Jakwerth, Constanze A. http://orcid.org/0000-0002-2902-0393
Feuerherd, Martin
Guerth, Ferdinand M.
Oelsner, Madlen
Schellhammer, Linda
Giglberger, Johanna
Pechtold, Lisa
Jerin, Claudia
Kugler, Luisa
Mogler, Carolin
Haller, Bernhard
Erb, Anna
Wollenberg, Barbara
Spinner, Christoph D.
Buch, Thorsten
Protzer, Ulrike
Schmidt-Weber, Carsten B. http://orcid.org/0000-0002-3203-8084
Zissler, Ulrich M.
Chaker, Adam M.
Funding for this research was provided by:
Deutsche Zentrum für Lungenforschung
Comprehensive Pneumology Center (CPC) Munich
Deutsche Forschungsgemeinschaft (398577603, TR22)
Bundesministerium für Bildung und Forschung (ESACPE, 01KI20169A)
Klinikum rechts der Isar der Technischen Universität München
Article History
Received: 28 December 2021
Revised: 7 February 2022
Accepted: 15 February 2022
First Online: 5 March 2022
Declarations
:
: Nasal curettages from SARS-CoV-2-infected individuals and controls were obtained from participants of HPOS, an observational longitudinal study to assess the impact of COVID-19 in the group of health professionals. This study was performed in line with the principles of the Declaration of Helsinki. Approval was granted by the Ethics Commission of the Technical University of Munich (ethics vote no. AZ 175/20 s). Informed consent was obtained from all individual participants included in the study prior to participation (Table InternalRef removed). In vivo mouse study experiments were pre-registered at ExternalRef removed (study title “Effect of drug on ACE2 levels in mice”; ExternalRef removed).
: Dr. Jakwerth reports grants from Federal Ministry of Education and Research, grants from European Institute of Innovation & Technology (EIT), during the conduct of the study. Mr. Feuerherd reports personal fees from Helmholtz Zentrum München and Dr. Höhnle AG, outside the submitted work. Dr. Spinner reports grants, personal fees, non-financial support, and other from AbbVie, grants, personal fees, non-financial support, and other from Apeiron, personal fees from Formycon, grants, personal fees, non-financial support, and other from Gilead Sciences, grants, personal fees, and other from Eli Lilly, grants, personal fees, non-financial support, and other from Janssen-Cilag, grants, personal fees, non-financial support, and other from GSK/ViiV Healthcare, grants, personal fees, non-financial support, and other from MSD, outside the submitted work. Prof. Dr. Buch reports personal fees from Virometix AG, other from Virometix AG, other from Trials24 GmbH, other from Clemedi AG, outside the submitted work. Prof. Dr. Protzer reports grants from the Federal Ministry of Education and Research, the German Center for Infection Research (DZIF), the German Research Foundation (DFG), the European Union via Horizon 2020, and the Bavarian Research Foundation during conduct of the study. She receives personal fees as an ad hoc scientific advisor from Abbvie, Arbutus, Gilead, GSK, Johnson & Johnson, Vaccitech. Prof. Dr. Schmidt-Weber reports grants from German Center for Lung Research (DZL), grants from Comprehensive Pulmonary Lung Center (CPC) Munich during the conduct of the study. Personal fees from Allergopharma and Bencard, outside the submitted work. Dr. Zissler reports grants from Federal Ministry of Education and Research, during the conduct of the study. Dr. Chaker reports grants for clinical studies and research and other from Allergopharma, ALK Abello, AstraZeneca, Bencard / Allergen Therapeutics, ASIT Biotech, Lofarma, GSK, Novartis, LETI, Inmunotek, Roche, Sanofi Genzyme, Zeller, and from the European Institute of Technology (EIT); has received travel support from the European Academy of Allergy and Clinical Immunology (EAACI), DGAKI, all outside the submitted work. In addition, Drs. Jakwerth, Feuerherd, Protzer, Schmidt-Weber, Zissler, and Chaker are named as inventors on the patent application “Novel approaches for treatment of SARS-CoV-2-Infection in a patient.” Mr. Guerth, Ms. Oelsner, Dr. Schellhammer, Ms. Giglberger, Ms. Pechtold, Dr. Jerin, Ms. Kugler, Dr. Mogler, Dr. Haller, Ms. Erb, and Prof. Dr. Wollenberg have nothing to disclose.