Villanueva, Jeanette E.
Walters, Stacey N.
Saito, Mitsuru
Malle, Elisabeth K.
Zammit, Nathan W.
Watson, Katherine A.
Brink, Robert
La Gruta, Nicole L.
Alexander, Stephen I.
Grey, Shane T.
Funding for this research was provided by:
National Health and Medical Research Council (1071916, 427695, 569825)
Australian Research Council (201302657)
Article History
Received: 27 July 2016
Accepted: 5 December 2016
First Online: 6 January 2017
Data availability
: All data generated or analysed during this study are included in this published article (and its supplementary information files).
: This work was supported in part by a philanthropic grant from the Ross Trust and grants from the National Health and Medical Research Council (NHMRC) (427695) and Australian Research Council (ARC; 201302657) awarded to STG. JEV and NWZ were each supported by an Australian Postgraduate Award. NLL is a Sylvia and Charles Viertel Senior Medical Research Fellow and is supported by funding from the NHMRC (1071916). STG is an ARC Future Fellow and an NHMRC Research Fellow (569825). The authors have no conflicting financial interests.
: The authors declare that there is no duality of interest associated with this manuscript.
: JEV and SNW conducted and analysed islet and skin transplant and histological studies. MS and SIA conducted and analysed heart transplant studies. JEV conducted and analysed in vitro T cells assays, cell signalling studies and T cell polarisation studies. NWZ and EKM established and analysed inhibitor and signalling studies. KAW and NLL designed, conducted, analysed and interpreted viral immunity experiments. RB generated critical genetic tools for the study. JEV and STG interpreted all findings and co-wrote the manuscript. All authors were involved in revising the article critically for important intellectual content and gave final approval of the version to be published. STG designed and led the study and, as guarantor, takes responsibility for the contents of the article.
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