McKeown, Nicola M.
Dashti, Hassan S.
Ma, Jiantao
Haslam, Danielle E.
Kiefte-de Jong, Jessica C.
Smith, Caren E.
Tanaka, Toshiko
Graff, Mariaelisa
Lemaitre, Rozenn N.
Rybin, Denis
Sonestedt, Emily
Frazier-Wood, Alexis C.
Mook-Kanamori, Dennis O.
Li, Yanping
Wang, Carol A.
Leermakers, Elisabeth T. M.
Mikkilä, Vera
Young, Kristin L.
Mukamal, Kenneth J.
Cupples, L. Adrienne
Schulz, Christina-Alexandra
Chen, Tzu-An
Li-Gao, Ruifang
Huang, Tao
Oddy, Wendy H.
Raitakari, Olli
Rice, Kenneth
Meigs, James B.
Ericson, Ulrika
Steffen, Lyn M.
Rosendaal, Frits R.
Hofman, Albert
Kähönen, Mika
Psaty, Bruce M.
Brunkwall, Louise
Uitterlinden, Andre G.
Viikari, Jorma
Siscovick, David S.
Seppälä, Ilkka
North, Kari E.
Mozaffarian, Dariush
Dupuis, Josée
Orho-Melander, Marju
Rich, Stephen S.
de Mutsert, Renée
Qi, Lu
Pennell, Craig E.
Franco, Oscar H.
Lehtimäki, Terho
Herman, Mark A.
Funding for this research was provided by:
Social Insurance Institution of Finland
Metagenics Inc.
Kuopio, Tampere and Turku University Hospital Medical Funds (X51001)
Diabetes Research Foundation of Finnish Diabetes Association
Research Institute for Diseases in the Elderly
Universiteit Leiden
The Netherlands Genomics Initiative
Municipality of Rotterdam
Erasmus Universiteit Rotterdam
Nestec. Ltd.
Tampereen TuberkuloosisäätiÖ
Paavo Nurmen Säätiö
American Heart Association (0730094N)
Juho Vainion Säätiö
National Institute of Neurological Disorders and Stroke
National Institute of Diabetes and Digestive and Kidney Diseases (5K01DK082729-04, DK063491, DK091718, DK100383, DK58845, R01DK078616)
Medicinska Forskningsrådet
National Human Genome Research Institute (U01HG004402)
ZonMw
Women and Infants Research Foundation
Suomen Kulttuurirahasto
Leids Universitair Medisch Centrum
Cancerfonden
Boston Area Diabetes, Endocrinology Research Center Feasibility Program (P30 DK057521)
Canadian Institutes of Health Research (MOP-82893)
Centre International de Recherche sur le Cancer
National Institute on Aging (R01AG023629)
Nederlandse Organisatie voor Wetenschappelijk Onderzoek
Emil Aaltosen Säätiö
Region Skåne
Ministerie van Volksgezondheid, Welzijn en Sport
SNP Health Association Resources (N01-HC-95159, N01-HC-95160, N01-HC-95161, N01-HC-95162, N01-HC-95163, N01-HC-95164, N01-HC-95165, N01-HC-95166, N01-HC-95167, N01-HC-95168, N01-HC-95169)
Dutch Science Organization (916.14.023)
Signe ja Ane Gyllenbergin Säätiö
Ministerie van Onderwijs, Cultuur en Wetenschap
Raine Medical Research Foundation
National Center for Advancing Translational Sciences (UL1TR000124)
United States-Israel Binational Science Foundation (2011036)
USDA Agriculture Research Service (58-1950-0-014)
European Commission
Suomen Akatemia (117787, 121584, 124282, 126925, 129378, 134309, 286284, 41071)
National Heart, Lung, and Blood Institute (HHSN268200800007C, HHSN268201100005C, HHSN268201100006C, HHSN268201100007C, HHSN268201100008C, HHSN268201100009C, HHSN268201100010C, HHSN268201100011C, HHSN268201100012C, HHSN268201200036C, HL034594, HL071981, HL105756, HL126024, N01HC25195, N01HC55222, N01HC85079, N01HC85080, N01HC85081, N01HC85082, N01HC85083, N01HC85086, N02-HL-6-4278, N02HL64278, R01HL071051, R01HL071205, R01HL071250, R01HL071251, R01HL071252, R01HL071258, R01HL071259, R01HL086694, R01HL087641, R01HL087652, R01HL103612, R01HL105756, R01HL120393, R01HL130114, R01HL59367, RR-024156, U01HL080295)
National Health and Medical Research Council Of Australia (003209, 403981)
Medicinska Fakulteten, Lunds Universitet
University of Western Australia
Government of Western Australia
Australian Goverment
National Health and Medical Research Council of Australia National Enabling Facility
Telethon Institute for Child Health Research
University of Western Australia Faculty of Medicine, Dentistry, and Health Sciences
National Institutes of Health (K08 HL112845, K24DK080140, KL2TR001109, R01 CA49449, R01-DK100425, U01DK078616, UL1RR025005, UM1 CA186107)
Boston Obesity Nutrition Research Center (DK46200)
City of Malmö
Påhlsson Foundation and the Swedish Heart and Lung Foundation
Centre National de Génotypage
Yrjö Jahnssonin Säätiö
Erasmus Medisch Centrum
Sydäntutkimussäätiö
Article History
Received: 4 November 2016
Accepted: 29 August 2017
First Online: 2 November 2017
Data availability
: The datasets generated during and/or analysed during the current study are available from the corresponding author on reasonable request.
: NMM received funding from the Boston Area Diabetes, Endocrinology Research Center Feasibility Program (P30 DK057521) to support part of this research, and she was funded in part by the US Department of Agriculture, under agreement No. 58-1950-0-014. MAH is supported by R01 DK100425. CES is supported by K08 HL112845. JBM is supported by K24DK080140 and U01DK078616. KLY is supported by KL2TR001109.
: BP serves on the Data and Safety Monitoring Board of a clinical trial funded by the manufacturer (Zoll LifeCor) and on the Steering Committee of the Yale Open Data Access Project funded by Johnson & Johnson. All other authors declare no conflict of interest.
: The authors’ responsibilities were as follows: NMM, HSD, JM and MAH: designed the study; NMM, HSD, JM, DEH, JCK-dJ, CES, TT, MG, RNL, DR, ES, ACF-W, DOM-K, YL, CAW, ETML, VM, KLY, KJM, LAC, C-AS, T-AC, RL-G, TH, WHO, OR, KR, JBM, UE, LMS, FRR, AH, MK, BMP, LB, AGU, JV, DSS, IS, KEN, DM, JD, MO-M, SSR, RdM, LQ, CEP, OHF, TL and MAH: played a role in acquisition of the data and critical revision of the manuscript for important intellectual content; NMM, HSD, JM, DEH, JCK-dJ, CES, TT, MG, RNL, DR, ES, ACF-W, DOM-K, YL, CAW, ETML, VM and MAH: contributed to statistical analyses; NMM, HSD, JM, DEH, JCK-dJ, CES, TT and MAH: interpreted data; NMM, HSD, JM, DEH, JCK-dJ, CES, TT, MG, RNL, DR, ES, ACF-W, DOM-K, YL, CAW, ETML, VM, JBM and MAH: contributed to writing of the manuscript; all authors read and approved the final version of the manuscript. NMM and HSD (joint co-first authors) are the guarantors of this work and, as such, had full access to all the data in the study and take responsibility for the integrity of the data and the accuracy of the data analysis.
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