Zammit, Nathan W. http://orcid.org/0000-0002-3694-2951
Wong, Ying Ying http://orcid.org/0000-0002-3472-5080
Walters, Stacey N. http://orcid.org/0000-0001-5937-2341
Warren, Joanna
Barry, Simon C. http://orcid.org/0000-0002-0597-7609
Grey, Shane T. http://orcid.org/0000-0003-2160-1625
Funding for this research was provided by:
National Health and Medical Research Council (1130222, 1140691, 1189235)
Juvenile Diabetes Research Foundation International (3-SRA-2018-604-M-B)
University of New South Wales
Article History
Received: 16 November 2022
Accepted: 14 March 2023
First Online: 14 June 2023
Acknowledgements
: We thank the Biological Testing Facility at the Garvan Institute of Medical Research for animal care. We thank M. Pasparakis (CECAD Research Center Cologne, Germany) for floxed p65 and NEMO mice.
: All data will be made available on request to the senior author.
: Open Access funding enabled and organized by CAUL and its Member Institutions. NWZ was supported by an Australian Postgraduate Award and is an International Pancreas and Islet Transplant Association (IPITA) Derek Gray Fellow. The research was supported by National Health and Medical Research Council (NHMRC) grants (1130222, 1189235) and the Australian Juvenile Diabetes Research Foundation (3-SRA-2018-604-M-B) to STG. STG is an NHMRC Senior Research Fellow (1140691).
: The authors declare that there are no relationships or activities that might bias, or be perceived to bias, their work.
: STG designed and generated all mouse models used in this study. NWZ performed the cell signalling studies. NWZ and SNW performed the mouse metabolic studies. SNW performed the minimal mass transplantation experiments. NWZ and JW performed genotyping, histopathology and beta cell mass analysis. YYW and SCB performed the bioinformatics analysis. All authors designed and interpreted the experiments, prepared the final figures, and contributed relevant text to the results and discussion. NWZ and STG co-wrote the manuscript. All authors approved the final manuscript. STG is the guarantor of this work.