Little, Karis
Singh, Aditi
Del Marco, Angel http://orcid.org/0000-0001-7911-2395
Llorián-Salvador, María http://orcid.org/0000-0002-1120-6579
Vargas-Soria, Maria
Turch-Anguera, Mireia http://orcid.org/0000-0002-1862-6285
Solé, Montse http://orcid.org/0000-0003-4240-6562
Bakker, Noëlle
Scullion, Sarah
Comella, Joan X. http://orcid.org/0000-0002-6218-0786
Klaassen, Ingeborg http://orcid.org/0000-0003-1695-9403
Simó, Rafael http://orcid.org/0000-0003-0475-3096
Garcia-Alloza, Monica http://orcid.org/0000-0003-1610-4114
Tiwari, Vijay K. http://orcid.org/0000-0003-0292-6635
Stitt, Alan W. http://orcid.org/0000-0002-8647-9918
,
Funding for this research was provided by:
European Commission (EU GA 847749)
Article History
Received: 12 December 2022
Accepted: 28 March 2023
First Online: 23 June 2023
Change Date: 20 August 2023
Change Type: Update
Change Details: Open Access license text has been added.
Acknowledgements
: The authors wish to thank K. Harkin (Queen’s University Belfast) for assistance with single-cell dissociation experiments. The authors would also like to acknowledge the support provided by Genomics Core Technology Unit (GCTU), as well as resources and consultancy provided by High Performance Computational Services (Kelvin Cluster) team and the Advanced Imaging Core Technology Unit (AICTU), Queen’s University Belfast. The authors thank the Animal Facility of the University of Cadiz and its personnel for their help and support and thank Servicios Centrales de Investigacion en Biomedicina (SC-IBM) from Universidad de Cadiz for the resources and technical support. Schematics were created with BioRender.com.
: The single-cell sequencing data that support this study are available at GEO accession GSE217665 (ExternalRef removed)
: This work is supported by the RECOGNISED consortium grant (EU GA 847749) to MGA and AWS and by the Deutsche Forschungsgemeinschaft TI 799/1-3 and Novo Nordisk Foundation P3110103 grants to VKT. MLS is funded by Maria Zambrano fellowship from Spanish Ministry of Science, Innovation and Universities, funded by European Union ‘Next Generation EU’ (Universitat Autònoma de Barcelona). The study funders were not involved in the design of the study; the collection, analysis, and interpretation of data; writing the report; and did not impose any restrictions regarding the publication of the report.
: AWS is an associate editor for Diabetologia. The authors declare that there are no other relationships or activities that might bias, or be perceived to bias, their work
: KL, AS and ADM contributed equally to experiments, analysis and writing of the manuscript. Authorship order in the manuscript was determined based on date of joining the project. MLS, MVS, MTA, MS, NB and SS contributed to data collection and analysis, and revision of the article drafts. JXC, IK, RS, MGA, VKT and AWS contributed to discussion, and reviewed/edited the manuscript. All authors approved the final version of the article. AWS is the guarantor of this work.