Tang, Haibo http://orcid.org/0000-0003-3269-7781
Wang, Jie
Deng, Peizhi
Li, Yalan
Cao, Yaoquan
Yi, Bo
Zhu, Liyong
Zhu, Shaihong
Lu, Yao
Funding for this research was provided by:
National Natural Science Foundation of China (81974054, 82170437)
National key research and development program (2022YFC3602400, 2022YFC3602401)
Central South University Innovation-Driven Research Program (2023CXQD007)
Natural Science Foundation of Hunan Province (2021JJ31039)
Article History
Received: 2 March 2023
Accepted: 22 May 2023
First Online: 4 August 2023
Acknowledgements
: Summary-level data for GWAS summary statistics with exposures and outcomes were contributed by the UK Biobank, GIANT, DIAGRAM, 70KforT2D and MAGIC consortium. Pretrained gene prediction models for TWAS were provided by D. Zhou from the Vanderbilt University Medical Center. We thank all investigators and authors for sharing these data.
: All data generated or analysed during this study are included in this main text.
: This work was supported by grants from National key research and development program (2022YFC3602400, 2022YFC3602401), National Natural Science Foundation of China (82170437, 81974054), Central South University Innovation-Driven Research Program (2023CXQD007) and Natural Science Foundation of Hunan Province (2021JJ31039).
: All authors declare that there are no relationships or activities that might bias, or be perceived to bias, their work.
: HT, SZ, LZ and YLu conceived the study. JW and PD performed the cell experiments. YLi and YC collected and organised the experimental data. JW, PD, YLi and YC drafted the method and results sections, and assisted with the introduction and discussion sections. HT performed the statistical analyses and wrote the manuscript. BY, SZ, LZ and YLu interpreted the data and reviewed the manuscript. YLu revised the manuscript critically. All authors approved the final version. YLu is the guarantor of this work and, as such, had full access to all the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis.