Thomaidou, Sofia http://orcid.org/0000-0003-1624-2138
Munoz Garcia, Amadeo http://orcid.org/0000-0002-8634-3244
de Lange, Sabine
Gan, Jin
van der Slik, Arno R. http://orcid.org/0000-0002-8920-0118
Hoeben, Rob C. http://orcid.org/0000-0001-9443-8377
Roep, Bart O. http://orcid.org/0000-0002-3110-7391
Carlotti, Françoise http://orcid.org/0000-0001-7929-8468
Zaldumbide, Arnaud http://orcid.org/0000-0001-6680-4456
Funding for this research was provided by:
Diabetes Fonds
European Federation of Pharmaceutical Industries and Associations
Juvenile Diabetes Research Foundation United States of America
Stichting Diabetes Onderzoek Nederland
Article History
Received: 15 May 2023
Accepted: 26 June 2023
First Online: 15 August 2023
Acknowledgements
: The authors would like to thank S. Cramer and M. Rabelink (both Cell and Chemical Biology Department, Leiden University Medical Center, the Netherlands) for technical help.
: The single-cell RNA-seq dataset is available from the Gene Expression Omnibus (GEO) using the accession number GSE218316 (ExternalRef removed). All data are available in the main text or the electronic supplementary material.
: This work is supported by DON and the Dutch Diabetes Research Foundation and by the Innovative Medicines Initiative 2 Joint Undertaking (IMI2-JU) under grant agreement no. 115797 (INNODIA). This Joint Undertaking receives support from the EU’s Horizon 2020 research and innovation programme and the European Federation of Pharmaceutical Industries and Associations (EFPIA), JDRF and Leona M. and Harry B. Helmsley Charitable Trust. BOR was supported by the Wanek Family Project for Type 1 Diabetes.
: The authors declare that there are no relationships or activities that might bias, or be perceived to bias, their work.
: ST designed and performed the experiments and wrote the manuscript. AMG analysed the single-cell RNA-seq dataset and wrote the manuscript. ARvdS, JG and SdL performed the experiments and analysed the data. FC, RCH and BOR interpreted the data and critically revised the manuscript. AZ supervised the project, designed the experiments and wrote the manuscript. All co-authors revised and approved the final manuscript. AZ is the guarantor of this work and, as such, had full access to all the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis.