Lee, Dong Hoon
Jin, Qi
Shi, Ni
Wang, Fenglei
Bever, Alaina M.
Liang, Liming
Hu, Frank B.
Song, Mingyang
Zeleznik, Oana A.
Zhang, Xuehong
Joshi, Amit
Wu, Kana
Jeon, Justin Y.
Meyerhardt, Jeffrey A.
Chan, Andrew T.
Eliassen, A. Heather
Clish, Clary
Clinton, Steven K.
Giovannucci, Edward L.
Li, Jun
Tabung, Fred K.
Funding for this research was provided by:
Yonsei University Research Fund (2023-22-0159)
Yonsei Signature Research Cluster Project (2021-22-0009)
National Institutes of Health (P01 CA87969, R00 CA207736, R01 CA50385, U01 CA167552, U01 CA176726, UM1 CA186107)
Article History
Received: 8 April 2023
Accepted: 31 August 2023
First Online: 11 October 2023
Acknowledgements
: The authors thank the participants and staff of the NHS and HPFS for their valuable contributions. The graphical abstract was created using BioRender.com.
: The datasets generated and analysed during the current study are available from the corresponding author on request.
: This work was supported by the National Institutes of Health research grants UM1 CA186107, U01 CA176726, U01 CA167552, P01 CA87969, R01 CA50385 and R00 CA207736. ELG is funded as an American Cancer Society Clinical Research Professor (CRP-23-1014041). This research was also supported by the Yonsei Signature Research Cluster Project (2021-22-0009) and the Yonsei University Research Fund of 2023-22-0159.
: JAM has served as an advisor/consultant to Merck Pharmaceutical and COTA Healthcare. KW is currently an employee and stockholder of Vertex Pharmaceuticals. This work was not funded by this commercial entity. The other authors declare that there are no relationships or activities that might bias, or be perceived to bias, their work.
: DHL, ELG, JL and FKT were involved in the study concept and design. FBH, AHE, CC, ELG and FKT participated in acquisition of data. DHL, QJ, NS, FW, LL, OAZ, JL and FKT were involved in statistical analysis. All authors participated in interpretation of data. DHL prepared the first draft of the manuscript. All authors participated in critical revision of the manuscript and approved the final version of the manuscript. The corresponding author (FKT) takes full responsibility for the work and/or the conduct of the study, had access to the data and controlled the decision to publish.