Gandasi, Nikhil R. http://orcid.org/0000-0001-9400-6494
Gao, Rui http://orcid.org/0000-0002-0845-1370
Kothegala, Lakshmi http://orcid.org/0000-0002-6938-620X
Pearce, Abigail http://orcid.org/0000-0001-9845-0541
Santos, Cristiano http://orcid.org/0000-0002-9972-5583
Acreman, Samuel http://orcid.org/0000-0001-5117-4447
Basco, Davide http://orcid.org/0000-0002-7984-5676
Benrick, Anna http://orcid.org/0000-0003-4616-6789
Chibalina, Margarita V. http://orcid.org/0009-0001-8430-0005
Clark, Anne http://orcid.org/0000-0001-5007-3513
Guida, Claudia http://orcid.org/0000-0001-9475-1064
Harris, Matthew http://orcid.org/0000-0002-7918-5735
Johnson, Paul R. V. http://orcid.org/0000-0003-3142-137X
Knudsen, Jakob G. http://orcid.org/0000-0001-7237-8457
Ma, Jinfang http://orcid.org/0000-0001-7940-8620
Miranda, Caroline http://orcid.org/0000-0002-4649-2093
Shigeto, Makoto http://orcid.org/0009-0004-2449-7610
Tarasov, Andrei I. http://orcid.org/0000-0002-8883-176X
Yeung, Ho Yan http://orcid.org/0000-0003-3087-238X
Thorens, Bernard http://orcid.org/0000-0002-3738-0129
Asterholm, Ingrid W. http://orcid.org/0000-0002-0755-5784
Zhang, Quan http://orcid.org/0000-0002-3626-4855
Ramracheya, Reshma http://orcid.org/0000-0001-6117-1936
Ladds, Graham http://orcid.org/0000-0001-7320-9612
Rorsman, Patrik http://orcid.org/0000-0001-7578-0767
Funding for this research was provided by:
Vetenskapsrådet (2013-7107, 2020-01463, 2020-02485)
University of Gothenburg
Article History
Received: 16 August 2023
Accepted: 18 October 2023
First Online: 21 December 2023
Acknowledgements
: We thank F. O’Harte (University of Ulster, Coleraine, Northern Ireland, UK) for the gift of the GRAs peptides N and R. We also thank S. Barg (Uppsala University, Uppsala, Sweden) for providing the PPPG-NPY adenovirus and H. Yan (REMD Biotherapeutics, USA) for the gift of REMD2.59.
: All data from this study are presented in the published article and the supplementary material. Additional information is available from the corresponding author upon request.
: Studies in Göteborg were covered by a Wallenberg Scholars Fellowship (PR), an International Recruitment Award (538-2013-7107) and project grants from the (2020-01463 and 2020-02485) from the Swedish Research Council (Vetenskapsrådet). NRG’s work in Göteborg was supported by a grant from the Novo Nordisk Foundation (NRG). Initial stages of the project were supported by Diabetes UK RD Lawrence Fellowship (RR and QZ), a Novo Nordisk University of Oxford postdoctoral fellowship (CG) and a project grant from the Rosetrees Trust (PR). The isolation of human islets was funded by the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC) (PRVJ and PR). The views expressed are those of the author(s) and not necessarily those of the NHS, the NIHR or the Department of Health. Studies in Cambridge were supported by the Rosetrees foundation (to HYY and GL) and an international scholarship from the Cambridge Trust (HYY). Work in Lausanne (BT) was supported by grants from the Swiss National Science Foundation and the European Research Council.
: The authors declare that there are no relationships or activities that might bias, or be perceived to bias, their work.
: This manuscript reports studies performed over 15 years and that have involved generations of students and postdoctoral fellows. Authorship is in strict compliance with the recommendations of ICMJE. The project was conceived by RR and PR. GL, RR and PR directed the experimental studies, supervised the analysis of the results and interpreted the findings in their respective laboratories. NRG, RG, LK, AP, CS, SA, AB, MVC, AC, CG, MH, JM, CM, MS, AIT, HYY, IWA and QZ designed and performed the experiments and analysed the data in collaboration with or under the guidance of GL, RR and PR. DB, JGK, PRVJ and BT provided valuable experimental models (knockout mice and human islets) and assisted with testing them. PR wrote the manuscript together with RR and GL. All authors contributed to the discussion and read and approved the final version of the manuscript. PR is the guarantor of the work and, as such, had full access to all of the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis.