Villalba, Adrian
Gitton, Yorick
Inoue, Megumi
Aiello, Virginie
Blain, Raphaël
Toupin, Maryne
Mazaud-Guittot, Séverine
Rachdi, Latif
Semb, Henrik
Chédotal, Alain
Scharfmann, Raphaël
Funding for this research was provided by:
Fondation pour la Recherche Medicale (EQU201903007793)
INSERM cross-cutting program HuDeCA 2018
European Union’s Horizon 2020 (874839)
Fondation Francophone pour la Recherche sur le Diabete
Foundation Bettencourt Schueller
Laboratoire d’Excellence consortium Revive (Investissements d'Avenir ANR-10-LABX-73-01)
Article History
Received: 5 December 2023
Accepted: 7 February 2024
First Online: 17 April 2024
Data availability
: The most relevant data generated or analysed during this study are included in this manuscript and the . Further datasets generated during the current study are available from the corresponding author upon request.
: This project has received funding from the European Union’s Horizon 2020 research and innovation programme under grant agreement no. 874839 (RS, HS), Inserm cross-cutting programme HuDeCA 2018 (RS, AC, SM-G), Fondation pour la Recherche Medicale EQU201903007793 (RS), l'Agence Nationale de la Recherche (ANR-19-CE16-0021-01, AC), the Foundation Bettencourt Schueller (RS) and the Fondation Francophone pour la Recherche sur le Diabete (FFRD) (RS). The RS laboratory belongs to the Laboratoire d’Excellence consortium Revive (Investissements d'Avenir ANR-10-LABX-73-01). AV is supported by postdoctoral grant from Laboratoire d’Excellence consortium Revive. MI is supported by Wellcome (215116/Z/18/Z) and thanks the PhD programme FIRE and the Graduate School EURIP of Université Paris Cité for their financial support. AC is a CIFAR fellow in the McMillan multiscale human programme.
: The authors declare that there are no relationships or activities that might bias, or be perceived to bias, their work.
: AV, YG, MI and RB performed tissue clearing, immunostaining, imaging, data visualisation and analysis. AV, VA and LR performed tissue processing and culture. MT and SM-G collected the human embryo samples. AV, YG, AC and RS wrote the manuscript. HS provided some of the protocols. All authors contributed to the discussion and interpretation of the results, critically reviewed the final draft of the article, and approved the final version. RS is the guarantor of this work.