Funding for this research was provided by:
Received: 29 October 2018
Accepted: 7 January 2019
First Online: 24 January 2019
Compliance with ethical standards
: Marija Barbateskovic: PhD student at the Copenhagen Trial Unit and the Centre for Research in Intensive Care. Søren Marker: PhD student at the Department of Intensive Care at Rigshospitalet and the Centre for Research in Intensive Care. Coordinating investigator of the randomised clinical trial ‘Stress Ulcer Prophylaxis in the Intensive Care Unit’ (SUP-ICU). Anders Granholm: Coordinating investigator of the SUP-ICU trial. Carl Thomas Anthon: Coordinating investigator of the SUP-ICU trial. Mette Krag: Coordinating investigator of the SUP-ICU trial. Janus Christian Jakobsen: Director of Research, Chief Physician, Department of Cardiology, Holbæk Sygehus, Holbæk, Denmark. Anders Perner: Head of Research at the Department of Intensive Care at Rigshospitalet. The intensive care unit receives support for research from CSL Behring, Fresenius Kabi, Ferring Pharmaceuticals and the Novo Nordisk Foundation. Dr Perner is initiator of the SUP-ICU trial. Jørn Wetterslev: Member of the Copenhagen Trial Unit task force for developing Trial Sequential Analysis theory, manual and software which is presently free-ware at ExternalRef removed. Dr Wetterslev is member of the SUP-ICU trial steering group. Morten Hylander Møller: Sponsor and initiator of the SUP-ICU trial.
: An approval by an ethics committee was not applicable.