Funding for this research was provided by:
Health Technology Assessment Programme (12/127/126)
Received: 22 July 2019
Accepted: 18 October 2019
First Online: 7 January 2020
: All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee (Oxford C REC: 14/SC/0157) and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.
: ISRCTN73485024; EudraCT: 2014-000792-11.
: This project was funded by the National Institute for Health Research (NIHR) HTA Programme (ref 12/127/126) and supported by NIHR Applied Research Centre (ARC) West Midlands. The views expressed are those of the author(s) and not necessarily those of the NIHR or the Department of Health and Social Care. Financial support was provided by the National Institute for Health Research Comprehensive Research Network, Intensive Care Foundation and Out of Hospital Cardiac Arrest Registry, which is funded by the British Heart Foundation and Resuscitation Council; and by Health Care Wales. The funders and study Sponsor had no role in the trial design, in the collection or analysis of the data, or in the writing of the manuscript.
: All authors have completed the ICMJE uniform disclosure form at ExternalRef removed and declare: support from the NIHR for the submitted work; no financial relationships with any organisations that might have an interest in the submitted work in the previous three years; GDP, CD, JN, JF have volunteer roles with the International Liaison Committee on Resuscitation, European (GDP, JN), UK (GDP, JN, CD) and Australian (JF) Resuscitation Councils.
: Requests for access to data from the study should be addressed to the corresponding author at firstname.lastname@example.org. The study protocol has been published. All proposals requesting data access will need to specify how it is planned to use the data, and all proposals will need approval of the trial co-investigator team.