Peters-Sengers, Hessel http://orcid.org/0000-0003-3145-864X
Butler, Joe M. http://orcid.org/0000-0001-6781-6408
Uhel, Fabrice
Schultz, Marcus J.
Bonten, Marc J.
Cremer, Olaf L.
Scicluna, Brendon P.
van Vught, Lonneke A.
van der Poll, Tom
de Beer, Friso M.
Bos, Lieuwe D. J.
Glas, Gerie J.
van Hooijdonk, Roosmarijn T. M.
Horn, Janneke
Schouten, Laura R. A.
Straat, Marleen
Wieske, Luuk
Witteveen, Esther
Reijnders, Tom D. Y.
Schuurman, Alex R.
van Engelen, Tjitske S. R.
Pereverzeva, Liza
Hoogendijk, Arie J.
Huson, Mischa A.
Wiewel, Maryse A.
Klouwenberg, Peter M. C. Klein
Ong, David S. Y.
Frencken, Jos F.
Koster-Brouwer, Maria E.
van de Groep, Kirsten
Verboom, Diana M.
,
Clinical trials referenced in this document:
Documents that mention this clinical trial
Source-specific host response and outcomes in critically ill patients with sepsis: a prospective cohort study
https://doi.org/10.1007/s00134-021-06574-0
Mortality and host response aberrations associated with transient and persistent acute kidney injury in critically ill patients with sepsis: a prospective cohort study
https://doi.org/10.1007/s00134-020-06119-x
Association between delay in intensive care unit admission and the host response in patients with community-acquired pneumonia
https://doi.org/10.1186/s13613-021-00930-5
Identification and validation of distinct biological phenotypes in patients with acute respiratory distress syndrome by cluster analysis
https://doi.org/10.1136/thoraxjnl-2016-209719
Funding for this research was provided by:
center for translational molecular medicine (04I-201)
Nierstichting (19OK009)
H2020 Health (847422)
ZonMw (09150161910033)
Article History
Received: 16 July 2021
Accepted: 31 October 2021
First Online: 13 December 2021
Declarations
:
: This research was performed within the framework of the Center for Translational Molecular Medicine (CTMM) (ExternalRef removed), project Molecular Diagnosis and Risk Stratification of Sepsis (Grant 04I-201). The sponsor CTMM was neither involved in the design and conduction of the study nor was the sponsor involved in collection, management, analysis, and interpretation of the data or preparation, review or approval of the article. Decision to submit the article was not dependent on the sponsor.
: The authors disclose that they do not have any potential conflicts of interest.
: Patients were included via an opt-out consent method approved by the institutional review boards of both hospitals (IRB No. 10-056C).
: Patients were included via an opt-out consent method approved by the institutional review boards of both hospitals (IRB No. 10-056C).
: Not applicable/all data used for the present study have been anonymized and the submission does not include information that may identify individual persons.
: Gene expression datasets are available at the Gene Expression Omnibus public repository of NCBI under accession number GSE65682. Other data generated and/or analyzed during the current study are available on reasonable request. All requests should be sent to t.vanderpoll@amsterdamumc.nl.
: HPS, JMB, FU, BPS, LAvV, and TvdP contributed to the study design. HPS, JMB, FU, BPS, LAvV, and TvdP accessed and verified the data. HPS, JMB, and TvdP drafted the manuscript. HPS and JMB performed all the data analyses. All the authors contributed to interpretation of the data, critically revised the content, and gave final approval for publication.