Text and Data Mining valid from 2017-05-13
Received: 13 April 2017
Accepted: 4 May 2017
First Online: 13 May 2017
Compliance with ethical standards
: The contents of this manuscript are solely the responsibility of the authors and do not necessarily reflect the views or policies of their employers. Sebastian Hoffmann, a self-employed consultant, was paid by the Evidence-Based Toxicology Collaboration (EBTC) for his work on this manuscript. Nancy B. Beck was employed by the American Chemistry Council, a trade association of U.S. chemical manufacturers. Sebastian Hoffmann, Martin L. Stephens, John R. Fowle III, Ian Kimber, Nancy B. Beck, Rob de Vries and Katya Tsaouin are members of the Board of Trustees of the EBTC, which is funded by Center for Alternatives to Animal Testing at Johns Hopkins Bloomberg School of Public Health and ExxonMobil Foundation. Hubert Dirven, Julie E. Goodman, Manoj M. Lalu, Kristina Thayer, Paul Whaley and Daniele Wikoff are members of the Scientific Advisory Council of the EBTC. Manoj Lalu was supported by The Ottawa Hospital Anesthesia Alternate Funds Association.