Wong, Ee Tsin
Szostak, Justyna http://orcid.org/0000-0002-6233-612X
Titz, Bjoern
Lee, Tom
Wong, Sin Kei
Lavrynenko, Oksana
Merg, Celine
Corciulo, Maica
Simicevic, Jovan
Auberson, Mehdi
Peric, Dariusz
Dulize, Remi
Bornand, David
Loh, Guo Jie
Lee, Kyeonghee Monica
Zhang, Jingjie
Miller, John H. IV
Schlage, Walter K.
Guedj, Emmanuel
Schneider, Thomas
Phillips, Blaine
Leroy, Patrice
Choukrallah, Mohamed Amin
Sierro, Nicolas
Buettner, Ansgar
Xiang, Yang
Kuczaj, Arkadiusz
Ivanov, Nikolai V.
Luettich, Karsta
Vanscheeuwijck, Patrick
Peitsch, Manuel C.
Hoeng, Julia
Article History
Received: 20 November 2020
Accepted: 3 March 2021
First Online: 7 May 2021
Declarations
:
: The testing facilities (Singapore and Neuchâtel) are owned by Philip Morris Products S.A. This work involved e-vapor formulations from Altria Client Services LLC (ALCS). All authors, except AB and WKS, are employees of ALCS or Philip Morris Products S.A. WKS is contracted and paid by Philip Morris Products S.A. AB is an employee of Histovia GmbH, which was contracted and paid by Philip Morris Products S.A to perform the histopathological analysis.
: All procedures involving animals were performed in a facility accredited by the Association for Assessment and Accreditation of Laboratory Animal Care (AAALAC) and licensed by the National Parks/Animal and Veterinary Service (AVS), with approval from an Institutional Animal Care and Use Committee and in compliance with the National Advisory Committee for Laboratory Animal Research Guidelines on the Care and Use of Animals for Scientific Purposes (NACLAR 2004).
: JSZ, ETW, KL, and WKS drafted the manuscript. JSZ analyzed the transcriptomics data. EG, MA, DP, RD, DB, and NVI conducted gene expression profiling. MAC and NS conducted methylation analysis. ETW, TL, GJL and SKW conducted the in vivo experiments. JZ and JHM processed test atmosphere carbonyl analyses. OL performed the lipidomics analysis. CM and MC conducted the multi-analyte profiling analysis. JSI and TS performed the iTRAQ analysis. BT and YX processed and evaluated transcriptomics data. BT processed and evaluated the lipidomics and iTRAQ data. AK set the capillary aerosol generator. AB analyzed histopathological data. PL performed statistical analysis. BP, KL, PV, KML, JH, and MCP participated in the design and conception of the study. All authors read and approved the final manuscript.