Maden, Charlotte H.
Fairman, David
Chalker, Michelle
Costa, Maria J.
Fahy, William A.
Garman, Nadia
Lukey, Pauline T.
Mant, Tim
Parry, Simon
Simpson, Juliet K.
Slack, Robert J.
Kendrick, Stuart
Marshall, Richard P. http://orcid.org/0000-0001-9243-8138
Funding for this research was provided by:
GSK
Article History
Received: 17 November 2017
Accepted: 14 February 2018
First Online: 12 March 2018
Compliance with ethical standards
: All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards. The study was approved by the South Central-Oxford A Research Ethics Committee, Bristol Research Ethics Committee Centre, Whitefriars, Level 3 Block B, Lewins Mead, Bristol, BS1 2NT. The study took place at Quintiles Drug Research Unit, 6 Newcomen Street, London SE1 1YR.
: All animal studies were ethically reviewed and carried out in accordance with the Animals (Scientific Procedures) Act 1986 and the GSK Policy on the Care, Welfare and Treatment of Laboratory Animals.
: Competing interests
: The authors declare the following interests: Tim Mant is an employee of and holds shares in QuintilesIMS and is also supported by the National Institute for Health Research (NIHR) Biomedical Research Centre at Guy’s and St Thomas’ NHS Foundation Trust and King’s College London. All other authors are employees of, and hold shares/stock options in, GSK.