Clergue-Duval, Virgile
Questel, Frank
Azuar, Julien
Paquet, Claire
Cognat, Emmanuel
Amami, Jihed
Queneau, Mathieu
Dereux, Alexandra
Barré, Thomas
Bellivier, Frank
Farid, Karim
Vorspan, Florence
Article History
Received: 2 March 2019
Accepted: 14 August 2019
First Online: 19 August 2019
Compliance with ethical standards
:
: Florence Vorspan reports grants from Fondation Pour la Recherche en Alcoologie and congress fees from Camurus AB Pharmaceutical, outside the submitted work. Julien Azuar reports grants from Fondation Pour la Recherche en Alcoologie, outside the submitted work. Frank Bellivier has received honoraria or research or educational conference grants from Bristol-Myers Squibb, Otsuka, Eli Lilly & Co., Servier, Takeda, Sanofi Aventis, Lundbeck, AstraZeneca, and the European Space Agency and has received peer review research funding from the Ministry of Research, Assistance Publique–Hôpitaux de Paris, the National Institute for Research (INSERM), and the NARSAD, outside the submitted work. Claire Paquet is a member of the International Advisory Boards of Lilly, is a consultant with Fujiribio, Alzohis, Neuroimmune, and Gilead, and is involved as an investigator in several clinical trials for Roche, Esai, Lilly, Biogen, Astra-Zeneca, Lundbeck, and Neuroimmune, outside the submitted work. Emmanuel Cognat is involved as an investigator in several clinical trials for Roche, Esai and Biogen, outside the submitted work. Virgile Clergue-Duval, Frank Questel, Karim Farid, Mathieu Queneau, Jihed Amami, Alexandra Dereux, and Thomas Barré have no conflict of interest to disclose.
: The study was conducted in accordance with the 1964 Helsinki declaration, its later amendments or comparable ethical standards, and to French laws on biomedical research (Loi Jardé 2014, décrets d’application 2017).
: Because those data were collected during care, because all patients were informed that their data could be used for research purposes, and because none of the patients or their legal representatives expressed opposition, we did not obtain formal written consent. Furthermore, our hospital has a specific authorization Number 2017–013 given on 19 January 2017 by the CNIL (Commission Nationale Informatique et Liberté, French national board for information systems and freedom) for the analysis of data collected during routine care.The legal representative of the patient whose brain 18FDG-PET is shown in Figs.InternalRef removedandInternalRef removedhas specifically agreed to the use of the images.