Received: 24 July 2019
Accepted: 9 December 2019
First Online: 3 January 2020
Compliance with ethical standards
: All applicable international, national and institutional guidelines for the care and use of animals were followed. All procedures performed in studies involving animals were in accordance with the ethical standards of the institution or practice at which the studies were conducted.
: GlaxoSmithKline reviewed the manuscript for factual accuracy.At the time of the study, Mayca Onega, Christopher Coello, Gaia Rizzo, Nicholas Keat, Joaquim Ramada-Magalhaes, Sara Moz, Sac-Pham Tang, Christophe Plisson, Lisa Wells, Sharon Ashworth, Roger Gunn and Jan Passchier were all employees of Imanova Ltd. (now Imanova Ltd. trading as Invicro). Nicholas Keat and Christophe Plisson also own shares in GlaxoSmithKline. Christine A. Parker, Pete Szeto, Robert J. Slack, Giovanni Vitulli and Frederick J. Wilson were employees of GlaxoSmithKline R&D and owned shares in the company. Pauline T. Lukey was a GSK employee and owned shares in the company at the time of the study. She now works or has worked as an independent consultant to GlaxoSmithKline R&D, the Francis Crick Institute, Syncona, Mereo BioPharma, Peptinnovate, BerGenBio and Morphic Therapeutics. Frederick J. Wilson was previously a consultant of ECNP R&S, GlaxoSmithKline R&D, IPPEC, King’s College London, Lundbeck A/S, Mentis Cura ehf and Pfizer Inc. and has received travel expenses as a guest speaker from Orion Pharma Ltd.