Funding for this research was provided by:
“la Caixa” Foundation (LCF/PR/GN17/10300004)
Alzheimer's Association (TriBEKa-17-519007)
Innovative Medicines Initiative (115952)
Received: 29 June 2020
Accepted: 20 December 2020
First Online: 22 February 2021
Change Date: 20 March 2021
Change Type: Update
Change Details: The name of Dr. Isadora Lopes Alves was modified so that it will be captured as: Given Name: Isadora Family Name: Lopes Alves.
Compliance with ethical standards
: Lyduine E. Collij; Gemma Salvadó; Mahnaz Shekari; Isadora Lopes Alves; Juhan Reimand; Alle Meije Wink; Marissa Zwan; Aida Niñerola-Baizán & Andrés Perissinotti all report no existing potential conflicts of interest relevant to this article.Prof. Philip Scheltens received grants from GE Healthcare, Piramal, and Merck, paid to his institution; he has received speaker’s fees paid to the institution Alzheimer Center, VU University Medical Center, Lilly, GE Healthcare, and Roche.Prof. Frederik Barkhof received payment and honoraria from Bayer-Schering Pharma, Sanofi-Aventis, Genzyme, Biogen-Idec, TEVA, Merck-Serono, Novartis, Roche, Jansen Research, IXICO Ltd., GeNeuro, and Apitope Ltd. for consulting; payment from the Serono Symposia Foundation, IXICOLtd, and MedScape for educational presentations; research support via grants from EU/EFPIA Innovative Medicines Initiative Joint Undertaking (AMYPAD consortium), EuroPOND (H2020), UK MS Society, Dutch MS Society, PICTURE (IMDI-NWO), NIHR UCLH Biomedical Research Centre (BRC), ECTRIMS-MAGNIMS.Prof. J. L. Molinuevo is currently a full-time employee of Lundbeck and priory has served as a consultant or at advisory boards for the following for-profit companies, or has given lectures in symposia sponsored by the following for-profit companies: Roche Diagnostics, Genentech, Novartis, Lundbeck, Oryzon, Biogen, Lilly, Janssen, Green Valley, MSD, Eisai, Alector, BioCross, GE Healthcare, ProMIS Neurosciences. He also received research support from the EU/EFPIA Innovative Medicines Initiative Joint Undertaking AMYPAD grant agreement n° 115952; the EU/EFPIA Innovative Medicines Initiative Joint Undertaking EPAD grant agreement n° 115736; the EU/EFPIA Innovative Medicines Initiative Joint Undertaking AETIONOMY grant n° 115568; and ‘la Caixa’ Foundation.Dr. J.D. Gispert has received speaker’s fees from Biogen and Philips. In addition he holds a ‘Ramón y Cajal’ fellowship (RYC-2013-13054) from the Spanish Ministry of Economy and Competitiveness, has received research support from the EU/EFPIA Innovative Medicines Initiative Joint Undertaking AMYPAD grant agreement n° 115952, and from Ministerio de Ciencia y Universidades (grant agreement RTI2018-102261).Prof. BN.M. van Berckel received research support from ZON-MW, AVID radiopharmaceuticals, CTMM and Janssen Pharmaceuticals. BvB is a trainer for Piramal and GE; he receives no personal honoraria.G Farrar, C Buckley and APL Smith are full-time employees of GE Healthcare.MD Ikonomovic has received research funding from GE Healthcare.No other potential conflicts of interest relevant to this article exist.
: The ALFA study and the PET sub-study protocols and informed consent forms have been approved by the independent Ethics Committee Parc de Salut Mar Barcelona and registered at ExternalRef removed (ALFA Identifier: NCT02485730; PET sub-study Identifier: NCT02685969). Both studies have been conducted in accordance with the directives of the Spanish Law 14/ 2007, of 3rd of July, on Biomedical Research (Ley 14/ 2007 de Investigación Biomédica). The medical ethics review committee of the VU University Medical Center approved the Dutch Flutemetamol study (reference number: 2012/302).
: Informed consent was obtained from all individual participants included in the study.