Ward-Kavanagh, Lindsay K. http://orcid.org/0000-0003-0898-4553
Kokolus, Kathleen M. http://orcid.org/0000-0002-9088-5409
Cooper, Timothy K.
Lukacher, Aron E. http://orcid.org/0000-0002-7969-2841
Schell, Todd D. http://orcid.org/0000-0002-6788-6518
Funding for this research was provided by:
National Cancer Institute (CA0250000, T32 CA060395)
National Institute of Allergy and Infectious Diseases (AI102543)
Article History
Received: 16 November 2017
Accepted: 3 January 2018
First Online: 13 January 2018
Conflict of interest
: The authors declare that they have no conflict of interest.
: All animal studies were approved by the Penn State Hershey Institutional Animal Care and Use Committee (Protocol #47088) and were performed in accordance with recommendations in the Guide for the Care and Use of Laboratory Animals.
: Mice were bred in specific pathogen-free barrier housing in the Penn State College of Medicine animal vivarium. RT4 mice on the C57BL/6J background were maintained as a homozygous line and bred with C57BL/6J mice to produce hemizygous RT4 mice for experiments. Hemizygous TCR-I mice were bred to homozygous B6.PL-Thy1a/CyJ females (the Jackson Laboratory) to generate CD90.1<sup>+</sup> donor T cells. TCR-I mice on the IFNγ-knockout background (TCR-IxGKO) were derived by backcrossing TCR-I mice to homozygous B6.129S7-<i>Ifng</i><sup> <i>tm1Ts</i> </sup>/J mice from the Jackson Laboratory.