Received: 25 July 2018
Accepted: 30 May 2019
First Online: 7 June 2019
Compliance with ethical standards
: The authors declare that they have no conflict of interest.
: This clinical study was conducted in accordance with the Helsinki declaration of 1975. The “Ethical Committee of the Fondazione Policlinico Universitario Agostino Gemelli IRCCS” approved the study with number 0049309/16.
: All the patients included in the study provided informed consent for the treatment in addition to the use of their specimens and data for research and publication purposes.