Bonaventura, Aldo http://orcid.org/0000-0002-4747-5535
Grossi, Francesco http://orcid.org/0000-0001-8412-3136
Carbone, Federico http://orcid.org/0000-0003-2957-4078
Vecchié, Alessandra http://orcid.org/0000-0003-0410-5996
Minetti, Silvia
Bardi, Nicholas
Elia, Edoardo
Ansaldo, Anna Maria
Ferrara, Daniele
Rijavec, Erika
Dal Bello, Maria Giovanna
Rossi, Giovanni http://orcid.org/0000-0001-8432-5408
Biello, Federica
Tagliamento, Marco
Alama, Angela http://orcid.org/0000-0002-9726-201X
Coco, Simona http://orcid.org/0000-0002-5296-4325
Spallarossa, Paolo
Dallegri, Franco http://orcid.org/0000-0001-9537-4547
Genova, Carlo http://orcid.org/0000-0003-3690-8582
Montecucco, Fabrizio http://orcid.org/0000-0003-0823-8729
Funding for this research was provided by:
Ministero della Salute
Fondazione Cassa di Risparmio di Genova e Imperia (N/A)
Article History
Received: 2 January 2019
Accepted: 5 July 2019
First Online: 20 July 2019
Compliance with ethical standards
:
: Francesco Grossi has consulting/advisory relationship with and received honoraria from Bristol-Myers Squibb, Merck Sharp & Dohme, and Pierre Fabre and has consulting/advisory relationship with AstraZeneca and Roche. Carlo Genova received honoraria from AstraZeneca, Boehringer-Ingelheim, Bristol-Myers-Squibb, Merck Sharp & Dohme, and Roche. Erika Rijavec received honoraria from Bristol-Myers Squibb. Paolo Spallarossa has consulting/advisory relationship with Incyte, Teva, Bristol-Myers Squibb and received honoraria from Incyte, Teva, and Servier. All other authors declare no conflicts of interest.
: The study was approved by the Institutional Review Board of IRCCS Ospedale Policlinico San Martino, Genoa, Italy (registry number: P.R. 191REG2015). The study was conducted in accordance with the Declaration of Helsinki and consistent with International Conference on Harmonization (ICH) Guidelines for Good Clinical Practice.
: Prior to inclusion in the study, all patients gave written, informed consent to the use of their samples and data for research and scientific publications.