Osborne, Nicholas http://orcid.org/0000-0002-0835-4802
Sundseth, Rebecca
Burks, Julian
Cao, Hong
Liu, Xunxian
Kroemer, Alexander H.
Sutton, Lynda
Cato, Allen
Smith, Jill P.
Funding for this research was provided by:
Cancer Advances, Inc
National Cancer Institute (CA051008)
Article History
Received: 24 January 2019
Accepted: 14 September 2019
First Online: 24 September 2019
Compliance with ethical standards
:
: Cato Research, Durham NC has intellectual property rights for PAS. PAS compound was transferred to Georgetown University by a Material Transfer agreement with Vaccicure Limited, Liverpool, UK for this research project. All authors work for Cato Research or Georgetown University.
: All applicable international, national, and/or institutional guidelines for the care and use of animals were followed. All procedures performed in studies involving animals were in accordance with the ethical standards of the Georgetown University. The IACUC Protocol Number was 2016-1193 and the protocol approval date was 10/05/2017.
: C57BL/6 mice were purchased from Charles River Laboratories (Maryland).
: Murine pancreatic cancer cells, mT3, were a gift from the Tuveson lab (Cold Spring Harbor, NY). Authentication of mT3 murine cells was performed by the investigator that developed the cells [CitationRef removed] and further IMPACT-III testing was performed by IDEXX BioResearch (Columbia, MO) to ensure the cells were pathogen-free.