Rashidi, Aida
Miska, Jason
Lee-Chang, Catalina
Kanojia, Deepak
Panek, Wojciech K.
Lopez-Rosas, Aurora
Zhang, Peng
Han, Yu
Xiao, Ting
Pituch, Katarzyna C.
Kim, Julius W.
Talebian, Mahsa
Fares, Jawad
Lesniak, Maciej S.
Funding for this research was provided by:
NIH/NCI (R35CA197725, R01NS093903)
NIH/NINDS (1F32NS098737-01A1)
Article History
Received: 10 May 2019
Accepted: 27 November 2019
First Online: 16 December 2019
Compliance with ethical standards
:
: The authors declare that they have no conflict of interest.
: The IACUC committee approved all animal work within the Center for Comparative Medicine (CCM) at Northwestern University. Northwestern University has an Animal Welfare Assurance on file with the Office of Laboratory Animal Welfare (A3283-01). Northwestern University conducts its reviews following United States Public Health Service (USPHS) regulations and applicable federal and local laws. The composition of the IACUC meets the requirements of the USPHS policy and the Animal Welfare Act Regulations. The animal protocol number is IS00002459.
: C57BL/6 (WT), GCN2 KO, Rag1 KO, OT-1, and Foxp3-IRES-GFP C57/B6 mice were purchased directly from The Jackson Laboratory (Bar Harbor, ME).
: GL-261 was purchased directly from the National Cancer Institute (NCI) Frederick National Tumor Repository Laboratory (Frederick, MD. USA). CT2A was acquired from the Balyasnikova laboratory at Northwestern University, Feinberg School of Medicine (Chicago, IL. USA). All cell lines were used in Northwestern’s Neuro-oncology research. All cell lines are routinely tested for Mycoplasma contamination every 2 months using the Universal Mycoplasma Detection Kit (ATCC<sup>®</sup> 30-1012 K™). The identity and purity of cell lines were determined using short tandem repeats (STR) profiling performed by the Northwestern sequencing facility.