Funding for this research was provided by:
Natural Science Foundation of China (81690262)
Article History
Received: 21 May 2019
Accepted: 13 June 2020
First Online: 24 June 2020
Compliance with ethical standards
:
: The authors declare no potential conflict of interest.
: The animal study protocol A2016014 was approved by the Experimental Animal Management Committee and Experimental Animal Ethics Committee of Shanghai Jiao Tong University following the recommendations in the Guide for the Care and Use of Laboratory Animals (Eighth Edition) and relevant Chinese laws and regulations.
: NOD/SCID mice were purchased from Beijing HFK Bioscience. FcRn humanized C57BL/6 mice were purchased from Beijing Biocytogen.
: HEK293-6E suspension cells expression system was purchased from ThermoFisher. CHO cells, Raji cells and CCRF-CEM cells were purchased from ATCC. PBMCs were purchased from all cells.