Russano, Marco http://orcid.org/0000-0002-6963-3864
Cortellini, Alessio http://orcid.org/0000-0002-1209-5735
Giusti, Raffaele http://orcid.org/0000-0003-4592-8868
Russo, Alessandro http://orcid.org/0000-0002-3365-1972
Zoratto, Federica
Rastelli, Francesca
Gelibter, Alain
Chiari, Rita
Nigro, Olga http://orcid.org/0000-0002-1030-2809
De Tursi, Michele http://orcid.org/0000-0002-1411-1946
Bracarda, Sergio
Gori, Stefania http://orcid.org/0000-0001-6320-405X
Grossi, Francesco http://orcid.org/0000-0001-8412-3136
Bersanelli, Melissa http://orcid.org/0000-0002-6527-6281
Calvetti, Lorenzo http://orcid.org/0000-0002-9135-8715
Di Noia, Vincenzo http://orcid.org/0000-0003-2009-5791
Scartozzi, Mario http://orcid.org/0000-0001-5977-5546
Di Maio, Massimo http://orcid.org/0000-0001-8906-3785
Bossi, Paolo http://orcid.org/0000-0003-0135-0224
Falcone, Alfredo http://orcid.org/0000-0001-5840-2529
Citarella, Fabrizio http://orcid.org/0000-0003-3096-4452
Pantano, Francesco http://orcid.org/0000-0002-2894-9686
Ficorella, Corrado
Filetti, Marco http://orcid.org/0000-0002-4734-7541
Adamo, Vincenzo http://orcid.org/0000-0003-2074-2418
Veltri, Enzo
Pergolesi, Federica
Occhipinti, Mario Alberto http://orcid.org/0000-0002-7169-5343
Nicolardi, Linda
Tuzi, Alessandro
Di Marino, Pietro
Macrini, Serena
Inno, Alessandro http://orcid.org/0000-0001-6331-6908
Ghidini, Michele http://orcid.org/0000-0001-5435-1218
Buti, Sebastiano http://orcid.org/0000-0003-0876-0226
Aprile, Giuseppe
Lai, Eleonora http://orcid.org/0000-0002-0275-8187
Audisio, Marco
Intagliata, Salvatore
Marconcini, Riccardo http://orcid.org/0000-0001-5120-911X
Brocco, Davide
Porzio, Giampiero http://orcid.org/0000-0002-9875-9220
Piras, Marta
Rijavec, Erika
Simionato, Francesca
Natoli, Clara http://orcid.org/0000-0001-7295-0230
Tiseo, Marcello http://orcid.org/0000-0002-9553-8465
Vincenzi, Bruno http://orcid.org/0000-0001-8222-9025
Tonini, Giuseppe http://orcid.org/0000-0003-4442-8677
Santini, Daniele http://orcid.org/0000-0002-9118-3337
Article History
Received: 6 July 2021
Accepted: 23 August 2021
First Online: 31 August 2021
Declarations
:
: Alessio Cortellini received speaker fees and grant consultancies from Roche, MSD, BMS, AstraZeneca, Novartis, Astellas. Marco Russano received honoraria for consultancy and scientific talks from Roche, BMS, MSD, Boehringer Ingelheim, AstraZeneca. Daniele Santini received speaker fees and grant consultancies from Janssen, Astellas, BMS, MSD, Pfizer, Boeringher Ingelheim, Roche, Eisai, Incyte, Novartis. Marcello Tiseo received speakers’ and consultants’ fee from AstraZeneca, Pfizer, Eli-Lilly, BMS, Novartis, Roche, MSD, Boehringer Ingelheim, Otsuka, Takeda, Pierre Fabre. Marcello Tiseo received institutional research grants from AstraZeneca, Boehringer Ingelheim. Sebastiano Buti received honoraria as a speaker at scientific events and advisory role by Bristol-Myers Squibb (BMS), Pfizer; MSD, Ipsen, Roche, Eli-Lilly, AstraZeneca, Pierre Fabre and Novartis.
: The study was approved by the respective local ethical committees on human experimentation of each institution, after previous approval by the coordinating center. The procedures followed were in accordance with the precepts of Good Clinical Practice and the declaration of Helsinki. IRB reference for the control cohort: University of L’Aquila, Internal Review Board protocol number 32865, approved on July 24th, 2018. IRB reference for the LTD cohort: Campus Bio-medico University of Rome, protocol number 37/19 OSS approved on July 24th, 2019.
: All patients alive at the time of data collection provided an informed consent for the present retrospective analysis.
: The authors affirm that human research participants provided informed consent for publication of the images.